促红细胞生成素在新生儿缺氧缺血性脑病中的应用效果

Application effect of Erythropoietin on neonatal hypoxic-ischemic encephalopathy

目的探讨促红细胞生成素(EPO)在新生儿缺氧缺血性脑病(HIE)中的应用效果。方法选取2016年3月~2018年9月我院收治的80例HIE患儿,依据随机数字表法分为对照组和观察组,每组各40例。对照组给予常规治疗,在此基础上观察组给予EPO治疗。治疗后,比较两组患儿治疗效果、行为神经、智能发育及出生质量。结果观察组总有效率95.00%(38/40)高于对照组的77.50%(31/40),差异有统计学意义(P=0.023);出生后2、4周,观察组的新生儿行为神经测定(NBNA)评分高于对照组,差异有统计学意义(P<0.05);出生3、6个月后时,观察组心理发展指数(PDI)与智能发育指数(MDI)评分高于对照组,差异均有统计学意义(P<0.05);出生10个月后,观察组的精神运动能区、大运动能区、语言能区、社会适应能区及个人社交能区评分均高于对照组,差异有统计学意义(P<0.05)。结论对HIE使用EPO治疗,有利于促进患儿恢复神经功能,改善智能发育,提升出生质量,值得临床推广。

Objective To investigate the application effect of Erythropoietin(EPO)on neonatal hypoxic-ischemic encephalopathy(HIE).Methods A total of 80 patients HIE with EPO treated in our hospital from March 2016 to September 2018 were selected and divided into control group and observation group by random number table method,40 cases in each group.The control group was given conventional treatment,and the observation group was given EPO treatment on the basis of the control group.After treatment,the therapeutic effect,the newborn′s neurobehavioral development,intellectual development and birth quality between the two groups were compared.Results The total effective rate in the observation group was 95.00%(38/40),higher than that of the control group,accounting for 77.50%(31/40),and the difference was statistically significant(P=0.023).The 2 and 4 week neonatal behavioral neurological assessment(NBNA)scores in the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).At 3 and 6 months after birth,the psychological development index(PDI)score and mental development index(MDI)score of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).After the age of 10 months,the scores of psychomotor function area,gross motor function area,language function area,social adaption function area,and personal social contact function area in the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion The use of EPO treatment for HIE is beneficial to promoting the recovery of neurological function,ameliorating intellectual development,and improving birth quality.It is worthy of clinical promotion.