首发精神分裂症患者脑电图特征及治疗后的变化

Electroencephalogram characteristics of patients with first-episode schizophrenia before and after treatment

目的探讨首发精神分裂症患者的脑电图特征及治疗后的变化。方法选取济宁市精神病防治院2015年2月至2019年8月收治的首发精神分裂症患者68例,且均分别于治疗前、阿立哌唑片治疗8周后接受脑电图检查。记录患者治疗前脑电图检查结果,并对治疗前脑电图检查异常的精神分裂症患者治疗后的脑电图检查结果进行对比分析。结果68例患者中,脑电图检查结果异常者占33.82%(23/68),脑电图正常者占66.18%(45/68),P<0.05;脑电图轻度异常、中度异常及正常精神分裂症患者不同导联脑电图δ波、θ波、α1波、α2波、β1波、β2波比较差异有统计学意义(P<0.05);68例精神分裂症患者治疗后脑电图检查结果异常率(23.53%,16/68)低于治疗前(33.82%,23/68),但差异未见统计学意义(P>0.05)。结论脑电图可作为诊断精神分裂症病情、判断患者疗效及评估预后的主要辅助检查项目之一,在临床诊治精神分裂症过程中发挥重要作用。

Objective To investigate the electroencephalogram(EEG)characteristics of patients with first-episode schizophrenics and the changes of EEG before and after treatment.Methods Sixty-eight patients with first-episode schizophrenics admitted to Jining Psychiatric Hospital from February 2015 to August 2019 were selected,and they received EEG examination before treatment and after 8 weeks of treatment with aripiprazole tablet.The results of EEG prior to treatment were recorded;after treatment,the results of two times of EEG were compared for patients who had abnormal presents in the first examination.Results Among 68 patients,33.82%(23/68)of the cases had abnormal EEG results,66.18%(45/68)of the cases had normal EEG results,and the difference in percentages of two kinds of EEG result was significant(P<0.05).There were significant differences inδwave,θwave,α1 wave,α2 wave,β1 wave andβ2 wave of EEG among patients with mild abnormal,moderate abnormal and normal schizophrenia(P<0.05).The abnormal rate of EEG of the 68 schizophrenics patients after treatment(23.53%,16/68)was lower than that before treatment(33.82%,23/68),but the difference was not significant(P>0.05).Conclusions EEG can be used as one of the main auxiliary examinations to diagnose the condition of schizophrenia,judge the curative effect and evaluate the prognosis.And it plays an important role in the clinical diagnosis and treatment of schizophrenia.