奥替溴铵联合双歧杆菌治疗腹泻型肠易激综合征的效果观察

Efficacy of octylonium combined with Bifidobacterium in the treatment of diarrhea irritable bowel syndrome

目的探究奥替溴铵与双歧杆菌联合应用于腹泻型肠易激综合征(D-IBS)患者的治疗效果,并观察其对患者神经肽Y(SPY)及炎性因子的影响。方法选取太原市中心医院2017年4月至2019年6月收治的82例D-IBS患者为研究对象,依据随机数字表法分为观察组及对照组,每组41例。对照组行双歧杆菌治疗,观察组在双歧杆菌治疗的基础上联合奥替溴铵治疗。观察两组患者的疗效、治疗前后SPY及白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)变化情况。结果观察组总有效率(97.56%,40/41)高于对照组(78.05%,32/41),χ2=7.289,P<0.05。治疗后,观察组SPY为(72.93±9.17)ng/ml,高于对照组的(61.98±7.30)ng/ml,t=5.982,P<0.05;观察组IL-1β、IL-18、TNF-α为(10.40±1.81)、(5.38±0.78)、(12.89±3.21)pg/ml,低于对照组的(16.22±3.21)、(7.28±0.94)、(19.30±4.27)pg/ml,P<0.05。结论奥替溴铵与双歧杆菌联合治疗D-IBS具有理想的疗效,对炎症反应起到显著地抑制作用,可缓解腹痛,促进脑肠轴功能恢复。

Objective To investigate the therapeutic effects of octylonium combined with Bifidobacterium on patients with diarrheal irritable bowel syndrome(D-IBS),and to observe its effects on neuropeptide Y(SPY)and inflammatory factors.Methods Eighty-two D-IBS patients hospitalized in Taiyuan Central Hospital from April 2017 to June 2019 were selected as the research objects.The selected patients were divided into observation group and control group according to the random number table method,with 41 patients in each group.The control group was treated with Bifidobacterium,and the observation group was treated with octylonium and Bifidobacterium.The efficacy,changes of SPY,interleukin-1β(IL-1β),interleukin-18(IL-18)and tumor necrosis factor-α(TNF-α)before and after treatment of the two groups were observed.Results The total effective rate of the observation group(97.56%,40/41)was higher than that of the control group(78.05%,32/41),χ2=7.289,P<0.05.After treatment,the SPY of the observation group was(72.93±9.17)ng/ml,which was significantly higher than the(61.98±7.30)ng/ml of the control group(t=5.982,P<0.05).After treatment,the levels of IL-1β,IL-18,TNF-αin the observation group were(10.40±1.81)pg/ml,(5.38±0.78)pg/ml,(12.89±3.21)pg/ml,respectively,lower than the(16.22±3.21)pg/ml,(7.28±0.94)pg/ml and(19.30±4.27)pg/ml in the control group,P<0.05.Conclusions Octylonium combined with Bifidobacillus has ideal curative effects in the treatment of D-IBS,which can significantly inhibit the expression of inflammatory factors,relieve abdominal pain and promote the recovery of gut-brain axis function.