中国的敬老院人群尿钠钾比值与血管僵硬度的相关性分析

Correlation analysis of urinary sodium-potassium ratio and vascular stiffness in elderly nursing homes in China

目的探讨中国敬老院老年人群点尿钠钾比值水平与动脉僵硬度的相关性。方法于2017年采用整群抽样方法,对中国北方7个敬老院人群进行问卷调查、体格检查和实验室检验,尿标本收集早晨7~9点的尿液,检测尿钾尿钠浓度,计算尿钠钾浓度的比值。测量颈股动脉脉搏波传导速度(cfPWV)来评估血管僵硬度,采用多元线性回归分析有无相关性。结果参与研究资料完整的350例(其中男性270例,女性80例)用于分析,平均年龄(70.92±12.76)岁,点尿的钠钾比值3.48±2.44。结果显示尿钠钾比值(r=0.142,P=0.008)、收缩压(r=0.458,P=0.000)、舒张压(r=0.424,P=0.000)、平均动脉压(r=0.479,P=0.000)、血糖(r=0.112,P=0.037)和三酰甘油LogTG(r=0.105,P=0.050)与cfPWV呈显著正相关。多元线性回归分析结果显示,以cfPWV为因变量,以年龄、性别、体质指数、血糖、三酰甘油、平均动脉压、尿钠钾比值为自变量,结果显示cfPWV与尿钠钾比值、年龄、平均动脉压、三酰甘油显著正相关。结论该人群中点尿钠钾比值不但与血压相关,还与动脉僵硬度有关,是动脉僵硬度的独立危险因素。

Objectives To explore the correlation between the urine sodium and potassium ratio and arterial stiffness in the elderly population in the Chinese nursing home.Methods In 2017,a cluster sampling method was used to conduct questionnaire surveys,physical examinations and laboratory tests on the population of 7 nursing homes in northern China.Urine samples were collected from urine at 7-9 o'clock in the morning to detect urine potassium and urine sodium concentration and calculate urine potassium urine sodium concentration ratio.Carotid femoral pulse wave velocity(cfPWV)was measured to assess vascular stiffness,and multiple linear regression analysis was used to determine whether there was any correlation.Results A total of 350 participants(270 males and 80 females)were used for analysis.The average age was(70.92±12.76)years old,and the urine sodium-topotassium ratio was 3.48±2.44.Urinary sodium to potassium ratio(r=0.142,P=0.008),systolic blood pressure(r=0.458,P=0.000),diastolic blood pressure(r=0.424,P=0.000),mean arterial pressure(r=0.479,P=0.000),blood glucose(r=0.112,P=0.037)and triglyceride LogTG(r=0.105,P=0.050)were significantly positively correlated with cfPWV.The results of multiple linear regression analysis showed that cfPWV was used as the dependent variable,and age,gender,body mass index,blood sugar,triglyceride,mean arterial pressure,and urine sodium potassium ratio were independent variables.The ratio of cfPWV to urine sodium potassium potassium,age,and mean artery Pressure and triglycerides were significantly positively correlated.Conclusion The midpoint urine sodium potassium ratio of this population is not only related to blood pressure,but also to arterial stiffness,which is an independent risk factor for arterial stiffness.