三酰甘油葡萄糖乘积指数对急性心肌梗死患者PCI预后的评估价值

Review value of triglyceride-glucose product index to prognosis in patients with acute myocardial infarction after PCI

目的检测急性心肌梗死患者三酰甘油葡萄糖乘积指数(TyG)大小情况,并探究TyG对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)预后的评估价值。方法选取2014年3月~2016年12月于湖北医药学院附属东风医院心血管内科确诊并住院治疗的急性心肌梗死患者70例为急性心肌梗死组,同期选取在本院进行常规检查人群60例为对照组。采用全自动生化分析仪检测所有研究对象的生化指标;采用超声心动图仪对各组研究对象的左室舒张末期内经(LVEDd)、左室射血分数(LVEF)和左房内径(LAD)进行检测。结果急性心肌梗死组TyG显著高于对照组(P<0.05);高TyG组患者肌酐(Cr)、超敏C-反应蛋白(hs-CRP)水平显著高于低TyG组(P<0.05),LVEF显著低于低TyG组(P<0.05);高低TyG组患者的尿素氮(BUN)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、LAD及LVEDd差异无统计学意义(P>0.05);高TyG组患者心力衰竭再住院、心肌梗死后心绞痛发生率显著高于低TyG组(P<0.05),再次血运重建、再发心肌缺血及死亡发生率与低TyG组比较差异无统计学意义(P>0.05)。结论在急性心肌梗死患者中TyG明显升高,且其数值高低与患者Cr、hs-CRP水平和LVEF及PCI预后密切相关,具有一定的评估价值,提示TyG可作为评估急性心肌梗死患者PCI预后的潜在指标。

Objective To detect the level of triglyceride-glucose product index(TyG),and study the review its value to the prognosis in patients with acute myocardial infarction(AMI)after PCI.Methods AMI patients(n=70)were chosen into AMI group from Department of Cardiovascular Medicine in Dongfeng Hospital affiliated to Hubei University of Medicine from Mar.2014 to Dec.2016,and at the same time patients received routine examinations(n=60)were chosen into control group.The biochemical indexes were detected by using automatic biochemical analyzer in 2 groups.The changes of left ventricular end-diastolic diameter(LVEDd),left ventricular ejection fraction(LVEF)and left atrial diameter(LAD)were observed by applying echocardiography in 2 groups.Results The level of TyG was significantly higher in AMI group than that in control group(P<0.05).The levels of creatinine(Cr)and high sensitivity C-reactive protein(hs-CRP)were significantly higher,and LVEF level was significantly lower in high TyG group than those in low TyG group(P<0.05).The difference in blood urea nitrogen(BUN),triglyceride(TG),low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),LAD and LVEDd had no statistical significance between high TyG group and low TyG group(P>0.05).The rate of readmission rate due to heart failure and incidence rate of post-infarction angina pectoris were significantly higher in high TyG group than those in low TyG group(P<0.05),and difference in incidence rates of re-revascularization and relapsed myocardial ischemia and mortality had no statistical significance between high TyG group and low TyG group(P>0.05).Conclusion The level of TyG increases significantly,and is closely correlated to Cr、Hs-CRP,LVEF and prognosis after PCI in AMI patients.TyG has some value and can be taken as a potential index for reviewing prognosis after PCI in AMI patients.