青年高尿酸血症患者危险因素分析及预防干预

Analysis of risk factors and preventive interventions for young patients with hyperuricemia

目的分析青年高尿酸血症(HUA)患者相关危险因素,研究探讨其综合预防干预措施。方法随机选取2018年1月至2018年12月于解放军总院第七医学中心急诊科符合研究标准的青年人群969例。根据血尿酸检验结果分为高尿酸组301例[男性血尿酸(SUA)>420μmol/L,女性SUA>360μmol/L]与正常对照组668例(男性SUA≤420μmol/L,女性SUA≤360μmol/L)。结果符合高尿酸血症者男性85.4%,女性14.6%,男性明显高于女性。高尿酸组患高血压病,高血糖,高血脂等各类代谢性疾病186例,检出率61.8%,超体质指数(BMI)104例,检出率34.6%。正常组患各类代谢性疾病150例,检出率22.5%,超BMI 6例,检出率0.01%。BMI、收缩压、肌酐、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白,两组检查结果比较,差异显著,有统计学意义(P<0.05)。舒张压、空腹血糖、尿素氮两组数值比较差异不显著,无统计学意义(P>0.05)。结论青年人群HUA的发生与男性不良的生活习惯及不健康的饮食结构造或超体质指数(肥胖)密切相关。医院及健康管理机构需针对青年人的特点和需要,制定行之有效的预防干预措施,防止HUA、痛风、高血压、高血脂、高血糖及心脑血管疾病的发生。

Objective To analyze the related risk factors of young patients with hyperuricemia and study their comprehensive preventive interventions.Methods A total of 969 young people were randomly selected from the emergency department of the seventh medical center of PLA General Hospital from January 2018 to December 2018.According to the results of blood uric acid test,301 people were divided into high uric acid group(male SUA>420μmol/L,female SUA>360μmol/L)and 668 people in normal control group(male SUA≤420μmol/L,female SUA≤360μmol/L).Results Among hyperuricemia patients,85.4%were males and 14.6%were females,and the proportion of male patients was significantly higher than that of females.In the high uric acid group,there were 186 people with various metabolic diseases such as hypertension,hyperglycemia,and hyperlipidemia,with a detection rate of 61.8%,and 104 people with a excess body mass index,with a detection rate of 34.6%.In the normal group,150 people suffered from various metabolic diseases with a detection rate of 22.5%,and 6 people with a excess body mass index had a detection rate of 0.01%.There were significant differences between the two groups in body mass index,systolic blood pressure,creatinine,total cholesterol,triglycerides,high-density lipoprotein and low-density lipoprotein(P<0.05).The diastolic blood pressure,fasting blood glucose,and urea nitrogen were not significantly different between the two groups,with no statistical significance(P>0.05).Conclusion The occurrence of hyperuricemia in young people is closely related to the poor lifestyle habits of men,unhealthy diet structure or excess body mass index(obesity).Hospitals and health management agencies need to formulate effective preventive interventions based on the characteristics and needs of young people to prevent the occurrence of hyperuricemia,gout,hypertension,hyperlipidemia,hyperglycemia and cardiovascular and cerebrovascular diseases.