长链非编码RNA在肝癌发生发展中的作用

Function of long non-coding RNA in the development of liver cancer

肝癌是人类常见的恶性肿瘤之一。肝癌病因复杂,影响因素较多,一般预后较差。近年来人们发现,许多长链非编码RNA(long non-coding RNA, lncRNA)参与了肝癌的发生发展,并影响其预后。其中部分lncRNA有望成为新的肝癌标志物。因此,深入研究lncRNA与肝癌的关系,明确其在肝癌中的功能对改善患者预后、降低患者死亡率有重要意义。本文主要综述了lncRNA在肝癌发生发展中的作用。

Liver cancer is one of the most common malignant tumors in human. The cause of liver cancer is complicated with many influencing factors, and the general prognosis is not satisfied. In recent years, it has been found that many long non-coding RNAs(lncRNA) are involved in the development of liver cancer and affect its prognosis. Some of these lncRNAs are expected to become new markers of liver cancer. Therefore, in-depth study of the relationship between lncRNA and liver cancer is important to improve patient prognosis and reduce patient mortality. This review summarized the function of lncRNA in the development of liver cancer.