重庆大足区新型冠状病毒肺炎患者出院后病毒核酸随访结果

Follow⁃Up Testing of Viral Nucleic Acids in Patients with COVID⁃19 in Dazu District,Chongqing,China

对重庆大足区新型冠状病毒肺炎确诊患者进行出院后病毒核酸随访,以明确复阳率及可检出病毒标本类型。对所有确诊患者进行定点隔离观察14d,之后再居家隔离4周,期间定期采集鼻咽拭子、口咽拭子、粪便、唾液和尿液5种标本进行新型冠状病毒核酸检测,同时密切关注病情变化。14人中共有6人复阳,3人为一过性复阳,另3人从出院到复阳时间间隔3~14d,持续12~18d后转阴,复阳患者未出现新临床症状且原有症状未加重,实验室检查和胸部CT平扫结果均无明显异常。其余8人截至隔离期结束均未复阳,未出现新型冠状病毒肺炎相关临床症状,实验室检查和影像学无异常。复阳患者中有2人的唾液标本中检出新型冠状病毒核酸。我区新型冠状病毒肺炎患者复阳比例较高,且新发现复阳患者唾液标本中携带新型冠状病毒,但是否具有感染性需要进一步验证。

To investigate the recurrence rate of coronavirus disease 2019(COVID-19)after discharge and type of SARS-CoV-2 nucleic acid-positive samples from patients with recurrence of SARS-CoV-2 in Dazu District,Chongqing,China,all patients were kept in isolation for 14 days,then quarantined at home for 4 weeks after discharge,during which time nasopharyngeal swabs,oropharyngeal swabs,feces,saliva,and urine were collected to test for SARS-CoV-2 nucleic acids by RT-PCR,and symptoms and signs were documented.Results showed that there were no symptoms or signs during isolation for any patient.However,specimens from three patients were confirmed positive for SARS-CoV-2 nucleic acids 3 to 14 days after discharge.SARSCoV-2 nucleic acids were detected in saliva samples from two patients with recurrence of SARS-CoV-2.The present study suggested that there is a relatively high incidence of positive tests for SARS-CoV-2 nucleic acids in patients after discharge.This is the first time that SARS-CoV-2 nucleic acids were detected in saliva samples.Whether the virus is infectious in these patients requires further study.