人呼吸道合胞病毒感染对机体Th1、Th2影响的研究进展

Research Progress in the Effects of Human Respiratory Syncytial Virus on Th 1 and Th2 in the Body

人呼吸道合胞病毒(Human respiratory syncytial virus,HRSV)感染是儿童时期罹患病毒性毛细支气管炎和肺炎的首要原因,与高发病率、住院率、死亡率明显相关。HRSV感染引起机体免疫应答失衡是导致发病的主要因素,其引发细胞介导的免疫应答方式常见的有辅助型T淋巴细胞1型(T-helper type 1,Th1)应答和辅助型T淋巴细胞2型(T-helper type 2,Th2)应答。这两种T细胞亚型的分化途径密切相关,两者之间的失衡可能在HRSV感染的发病机制中起重要作用。进一步研究和阐明HRSV感染对机体Th1、Th2之间免疫应答的作用机制将对寻找具有治疗作用的潜在靶标、通路,设计、研制安全有效的HRSV疫苗和药物具有至关重要的推动作用。

Human respiratory syncytial virus(HRSV)infection is the leading cause of viral bronchiolitis and pneumonia in childhood,and has obvious correlation with high morbidity,hospitalization rate and mortality.The imbalance of immune response caused by HRSV infection is a major factor in the pathogenesis.The virus infection induces cell-mediated immune response,including T-helper type 1(Th1)response and T-helper type 2(Th2)response.The differentiation pathways of these two T cell subtypes are closely related,and the imbalance between these two subtypes may play an important role in the pathogenesis of HRSV infection.Further study to elucidate the mechanism of HRSV infection on the immune response between Th1/Th2 will be of vital importance for finding potential therapeutic targets and pathways,as well as designing and developing safe and effective HRSV vaccines and drugs.