病毒诱导的细胞自噬与凋亡的串话关系研究进展

Research Progress in the Crosstalk Between the Autophagy and Apoptosis Induced by Viruses

很多研究表明,病毒感染细胞后能诱导自噬和凋亡。作为两种关键的细胞命运决定途径,自噬和凋亡在病毒与宿主细胞相互作用中发挥着非常重要的作用。本文综述了目前已报告的诸如疱疹病毒、黄病毒、正粘病毒和副粘病毒等13个病毒科病毒成员感染宿主细胞后诱导的自噬和凋亡串话关系研究进展,探讨了病毒感染引发的自噬和凋亡对病毒子代复制和细胞抗病毒免疫等方面的作用,将为未来深入研究自噬和凋亡及其串话调控在病毒侵染宿主过程中的主要作用奠定坚实基础,并为开发相应的病毒防控技术提供理论依据。

Several studies have shown that viruses could induce autophagy and apoptosis after infection.As two key cell fate determination pathways,autophagy and apoptosis have important roles in the interactions between viruses and host cells.Here,we provide a systematic review on research progress of the crosstalk between the autophagy and apoptosis induced by viruses belonging to 13 viridae,including Herpesviridae,Flaviviridae,Orthomyxoviridae,Paramyxoviridae and so on.The impact on the viral replication cycle and cellular antiviral immune process of virus-induced autophagy and apoptosis was also investigated.This work could help to provide solid knowledge for future study on the regulation of autophagy and apoptosis after viral infection,and even to establish antiviral solutions for different viral diseases.