脂肪细胞的分化形成与天然产物调控

Differentiation and Formation of Adipocytes and Regulative Role of Natural Organic Compounds

研究脂肪生成的机理及其调控过程对于防治动物肥胖引起的相关疾病、改善肉品风味和质量以及畜牧生产效率具有重要意义。脂肪细胞起源于多能性骨髓间充质干细胞(MSCs),接受细胞外刺激因子后迅速引起早期脂肪调节因子、C/EBPβ和C/EBPδ的表达,并传递信息至PPARγ和C/EBPα等转录因子,促进细胞的分化和脂滴形成。在此过程中,众多转录因子和细胞周期蛋白参与前体脂肪细胞到脂肪细胞的分化与成脂过程。植物来源的多种天然产物,如多酚类、生物碱、萜类、醌类化合物在脂肪细胞分化和抑制脂肪生成过程中发挥重要的调控作用,对这些天然化合物的深入和成药研究有望成为具有抑制细胞内脂滴聚集的潜在药物。

The elucidation of fat synthesis mechanisms and related regulative process is meaningful for preventing and curing a variety of obesity-associated diseases, ameliorating meat flavor and quality, and improving livestock production efficiency.Adipocytes originate from pluripotent mesenchymal stem cells(MSCs) in bone marrow. After receiving extracellular stimulating factors, they quickly induce the expression of early fat regulatory factors, C/EBPβ and C/EBPδ, and transmit information to PPARγ, C/EBPα and other transcription factors that promote cells differentiation and lipid droplets formation. There are varieties of transcription factors and cyclins involved in the process of differentiation of pre-adipocytes to adipocytes and adipogenesis.Studies have shown that some natural organic compounds derived from plants, such as polyphenols, alkaloids, terpenes and quinones, play important regulative roles in differentiation of adipocytes and inhibition of adipogenesis. More investigations on natural products must be done before developing medicines treatment for obesity-associated diseases through suppression of lipid droplets accumulation in cells.