南京市2014—2019年HIV抗体复检与梅毒感染情况

HIV antibody reexamination and syphilis infection in Nanjing from 2014 to 2019

目的:了解南京市初筛HIV抗体阳性样本复检结果及其梅毒感染情况。方法:用两种不同原理试剂进行复检,复检有反应样本,同时做WB确证试验、梅毒血清学RPR和RT检测。结果:南京市2014—2019年HIV抗体复检反应率呈现逐年下降趋势。男性、19~40岁和41~60岁、未婚人群和高学历人群的复检有反应率均高于相应对照组(均P<0.05)。在复检有反应的样本中,男性、19~40岁和41~60岁、未婚人群和退休/企事业梅毒的感染率高于相应对照组(均P<0.05)。结论:有必要加强HIV初筛实验室检测试剂的特异性,提高复检有反应率。加强可疑HIV感染人群中梅毒的检测工作。建议疾控部门依托医疗机构积极开展预防干预合并感染情况,采用HIV与梅毒防控一体化模式,建立高危人群的专门门诊,实现公共卫生服务和医疗服务一体化。

Objective:To understand the reexamination results of HIV antibody positive samples and syphilis infection in Nanjing city.Methods:The reexamination was carried out with two reexamination reagents of different principles.For the reexamination of the samples that responded,WB confirmation test,syphilis serological RPR and RT tests were performed at the same time.Results:From 2014 to 2019,the response rate of HIV antibody retesting decreased year by year in Nanjing.The response rate of male in 19-40 and 41-60 year old group,unmarried group and high education group was higher than that of the corresponding control group(all P<0.05).In the samples that responded to the reexamination,the infection rate of HIV in men,19-40 years old and 41-60 years old groups,unmarried people and retired/enterprise/business groups was higher than that in the corresponding control group(all P<0.05).Conclusion:It is necessary to strengthen the specificity of HIV testing reagent in the primary screening laboratory and improve the retesting response rate.Detection of syphilis should be carried out in suspected HIV infected people.It is suggested that the department of disease control should actively carry out the prevention and intervention of coinfection by relying on medical institutions,adopt the integrated mode of HIV and syphilis prevention and control,establish special outpatient clinics for high-risk groups,and realize the integration of public health services and medical services.