从代谢产物论述肠道菌群与阿尔茨海默病

Discussion of Intestinal Flora and Alzheimer′s Disease from the Perspective of Metabolites

阿尔茨海默病(Alzheimer′sDisease,AD)是最常见的一种痴呆类型,其主要表现为记忆、语言和认知能力的逐渐丧失。肠道菌群(Gut Microbiota,GM)作为近年来的探讨热点,引起学者们的广泛关注。有研究证明肠道菌群与阿尔茨海默病密切相关,其可通过代谢产物等多种方式来参与AD的发生与发展,从代谢产物三甲胺N-氧化物、γ-氨基丁酸、乙酰胆碱、β-甲基氨基-L-丙氨酸等来论述肠道菌群与阿尔茨海默病的关系。

Alzheimer′s Disease(AD),is the most common form of dementia characterized by progressive loss of memory,language and cognitive ability.As a hot topic in recent years,enteric microbial population(EMP)has attracted wide attention from scholars.Studies have proved that intestinal flora is closely related to Alzheimer′s Disease,and it can participate in the occurrence and the development of AD in a variety of ways including metabolites.This paper discourses on the relationship between intestinal flora and Alzheimer′s Disease from the metabolites trimethylamine N-oxide,γ-aminobutyric acid,acetylcholine,β-methylamino-L-alanine,etc.