复方大黄净化液对慢性肾衰竭大鼠的治疗

Treatment of compound rhubarb purifying solution on rats with chronic renal failure

为研究复方大黄净化液灌肠对慢性肾衰竭大鼠的治疗作用,通过复制慢性肾衰竭模型,分为病理对照组、药用炭组、复方大黄净化液大、中、小剂量灌肠治疗组,用药周期为58 d,测定了大鼠血清肌酐、尿素氮、尿肌酐、红细胞计数、血红蛋白含量及肾脏组织病理学变化。结果表明,复方大黄净化液各剂量组、药用炭组血清肌酐、尿素氮显著降低(P<0.05),且以复方大黄净化液大、中剂量组下降更为明显(P<0.05);复方大黄净化液各剂量组24 h尿肌酐显著升高(P<0.05),且以复方大黄净化液大、中剂量组更为明显(P<0.05);复方大黄净化液大、中剂量组红细胞计数、血红蛋白含量显著提高(P<0.05);灌肠后各剂量组可不同程度改善肾衰竭大鼠肾脏病理改变。复方大黄净化液对慢性肾衰竭大鼠肾功能、肾脏病理、贫血都具有一定改善作用,且存在量效依赖关系。

In order to explore the therapeutic effect of compound rhubarb purifying solution enema on chronic renal failure rats,it was divided into pathological control group,medicinal charcoal group,large,medium and small dose of compound rhubarb purifying solution enema treatment group by copying chronic renal failure model,the medication period was 58 d.The changes of serum creatinine,urea nitrogen,urine creatinine,red blood cell count,hemoglobin content,and renal histopathology were observed.Results showed that the blood muscle crispness and urea nitrogen of the compound rhubarb purifying solution in each dose group and the medicinal charcoal group were significantly reduced(P<0.05),and the decline was more significant in the large and medium dose groups(P<0.05).The 24-hour urinary muscle crunch in each dose group was significantly increased(P<0.05),and it was significant in the large and medium dose groups(P<0.05);the red blood cell count and hemoglobin content in the large and medium dose groups of compound rhubarb cleansing solution were significant increased(P<0.05);each dose group of enema formula can improve renal pathological changes in rats with renal failure to varying degrees.Compound rhubarb purifying solution had certain effects on improving renal function,renal pathology,and anemia in rats with chronic renal failure,and had a certain amount of effect.