环状RNA与感染性疾病的研究进展

Research progress on circRNA and infectious diseases

环状RNA(circRNA)是一种圆形闭环RNA,由于缺少5′端的帽子结构和3′端多聚腺苷酸化的尾部结构,使其表达更加稳定。作为RNA研究领域的热点,目前发现环状RNA与包括神经系统疾病、肿瘤及糖尿病等多种疾病的发生存在关联。感染性疾病是指细菌、病毒、真菌、寄生虫等侵入人体,在体内生长、繁殖,导致机体的正常代谢功能受损、组织结构破坏,引起局部组织发生损伤性病变和全身性炎症反应的疾病。目前发现,circRNA与许多感染性疾病的发生存在关系。文章就circRNA与感染性疾病的研究进展作一综述。

CircRNA is a kind of circular and closed-loop RNA.Because circRNA does not have 5′-end hat structure and 3′-end polyadenosine acidified tail structure,the expression of circRNA is more stable.As a hot spot in the field of RNA research,circRNA has been found to be associated with the occurrence of many diseases,including nervous system diseases,tumors,and diabetes.Infectious diseases refer to the local traumatic lesions and systemic inflammatory reactions related to impaired metabolic functions and tissue structures caused by the invasion,growth,and reproduction of bacteria,viruses,fungi,parasites and others in the human body.Current studies have proved that circRNA is associated with the occurrence of many infectious diseases.The paper reviewed the research progress on circRNA and infectious diseases.