参松养心胶囊防治中青年马拉松选手运动中室性心律失常的作用

Effects of Shensongyangxin capsule on ventricular arrhythmias in young and middle-aged Marathon runners

目的:观察参松养心胶囊防治中青年马拉松选手运动中室性心律失常的作用。方法:连续入选200例拟参加马拉松比赛的业余选手,随机分为2组:A组100例,进行静息状态下心电图+超声心动图(心超)检查;B组100例,进行运动平板心电图+运动负荷心超检查,比较两组室性心律失常的检出率。进一步筛选出B组中同时符合运动平板心电图检出室性心律失常和负荷心超正常者入选药物治疗组,给予参松养心胶囊治疗1个月,再次复查运动平板心电图,比较治疗前后室性心律失常的发生情况。结果:A组检出各类室性心律失常计4例(4%);B组检出室性心律失常22例(22%)。根据入组要求,19例入选药物治疗组,经参松养心胶囊治疗1个月后,再次复查运动平板心电图,仅1例检出频发室性早搏,其余18例参加马拉松比赛均未发生心血管不良事件或不适症状。非药物治疗组181例,其中169例参加了马拉比赛,有9例发生了主要心血管不良事件。结论:中青年马拉松选手在赛前进行运动负荷状态下心脏检查时室性心律失常检出率更高,参松养心胶囊对于防治运动中出现的室性心律失常安全、有效。

Objective:To investigate the effects of Shensongyangxin capsule on ventricular arrhythmias in young and middle-aged Marathon runner. Methods:A total of 200 amateur Marathon runners were consecutively enrolled and randomly divided into two groups, namely group A(underwent resting electrocardiogram(ECG) and transthoracic echocardiography(TTE), n=100) and group B(underwent excrcise ECG and excrcise TTE, n=100). The detection rates of ventricular arrhythmias were compared between two groups. Participants in group B, who met both following criteria:(1) Ventricular arrhythmias occurred during exercise ECG.(2)The result of exercise TTE was normal, were given Shensongyangxin capsule regularly for one month. Another excrcise ECG was subsequently arranged after medicine treatment and compared the incidences of ventricular arrhythmias before and after treatment. Results:In group A, ventricular arrhythmias were recorded in 4(4%) participants;while in group B, ventricular arrhythmias were found in 22(22%). Furthermore, a total of 19 participants were included in medicine treatment group. After a regular treatment with Shensongyangxin capsule, another excrcise ECG was performed, showing only one case of frequent premature ventricular complex. The other 18 participants in medicine treatment group ran a Marathon with no cardiovascular adverse event or symptomatic episode. Of 181 participants without medicine treatment, 169 people experienced Marathon running, and major cardiovascular adverse events occurred in 9 runners. Conclusions:In the young and middle-aged Marathon runners, exercise cardiac screening before race can detect more cases of ventricular arrhythmias. Additionally, Shensongyangxin capsule is safe and effective in preventing ventricular arrhythmias during exercises.