血清碱性磷酸酶水平与冠状动脉钙化的相关性研究

Correlation between Serum Alkaline Phosphatase and Coronary Artery Calcification

【目的】探讨血清碱性磷酸酶(ALP)水平与冠状动脉钙化程度的相关性。【方法】回顾性分析苏州市中医医院行128层冠状动脉CT扫描的住院患者154例。根据冠状动脉CT钙化积分评价冠状动脉钙化的严重程度,并测定患者血清碱性磷酸酶水平。根据患者钙化积分分钙化组和非钙化组,比较两组患者的临床资料和ALP水平,并进一步分析钙化组患者冠状动脉钙化积分和血清ALP水平、年龄、血脂指标的相关性。【结果】钙化组与非钙化组患者的年龄、吸烟史、糖尿病史、高血压史及血清高密度脂蛋白胆固醇(HDL-C)、ALP水平比较,差异有统计学意义(P<0.05);性别、饮酒史及血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平比较,差异无统计学意义(P>0.05)。钙化组钙化积分与年龄、ALP呈显著正相关(P<0.01),钙化积分与HDL-C呈负相关(P=0.016<0.05),钙化积分与TC、TG、LDL-C无相关性(P>0.01)。【结论】血清碱性磷酸酶水平与冠状动脉钙化密切相关,可作为冠状动脉钙化诊断的生物学指标。

【Objective】To explore the relationship between serum alkaline phosphatase and coronary artery calcification.【Methods】A total of 154 hospitalized patients underwent 128-layer coronary artery CT scan in Suzhou traditional Chinese Medicine Hospital.According to the coronary artery CT calcification score,the severity of coronary artery calcification was evaluated,and the serum alkaline phosphatase level was measured.The patients were divided into calcified group and non-calcified group according to the calcification score.The clinical data and ALP level of the patients in the two groups were compared,and the correlation between coronary artery calcification score and serum ALP level,age and blood lipid index in the calcified group was further analyzed.【Results】There were significant differences in age,smoking history,diabetes mellitus history,hypertension history and serum high density lipoprotein cholesterol(HDL-C)and ALP levels between calcification group and non calcification group(P<0.05);there were no significant differences in gender,drinking history,serum total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG)(P>0.05).In calcification group,calcification score was significantly positively correlated with age and ALP(P<0.01),and negatively correlated with HDL-C(P=0.016<0.05),but there was no correlation between calcification score and TC,TG,LDL-C(P>0.01).【Conclusion】Serum alkaline phosphatase level is closely related to coronary artery calcification,which can be used as a biological index for the diagnosis of coronary artery calcification.