屈螺酮炔雌醇片联合二甲双胍治疗多囊卵巢综合征的临床效果研究

Clinical effect of drospirone and ethinylestradiol tablets combined with metformin in the treatment of polycystic ovary syndrome

目的探讨屈螺酮炔雌醇片联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床效果。方法90例PCOS患者,随机分为观察组和对照组,各45例。对照组单纯使用屈螺酮炔雌醇片进行治疗,观察组在对照组的基础上添加二甲双胍进行治疗。对比两组各项检测指标;治疗后的排卵率及妊娠率;临床疗效;不良反应发生情况。结果治疗后,两组黄体生成素(LH)、LH/卵泡刺激素(FSH)、睾酮(T)、体质量指数(BMI)均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的排卵率64.44%及妊娠率37.78%均高于对照组的37.78%、15.56%,差异有统计学意义(P<0.05)。观察组患者的治疗总有效率91.11%高于对照组的73.33%,差异有统计学意义(P<0.05)。观察组不良反应总发生率11.11%低于对照组的28.89%,差异有统计学意义(P<0.05)。结论屈螺酮炔雌醇片联合二甲双胍治疗PCOS可明显提高卵巢机能,临床应用安全有效,值得临床推广应用。

Objective To discuss the clinical effect of drospirone and ethinylestradiol tablets combined with metformin in the treatment of polycystic ovary syndrome(PCOS).Methods A total of 90 PCOS patients were randomly divided into observation group and control group,with 45 cases in each group.The control group was treated by drospirone and ethinylestradiol tablets,and the observation group was treated by metformin on the basis of the control group.The ovulation rate and pregnancy rate after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results After treatment,the luteinizing hormone(LH),LH/follicle stimulating hormone(FSH),testosterone(T),body mass index(BMI)of the two groups was lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the ovulation rate 64.44%and pregnancy rate 37.78%of the observation group was higher than that of the control group 37.78%and 15.56%,and the difference was statistically significant(P<0.05).The total effective rate of treatment 91.11%of the observation group was higher than that of the control group 73.33%,and the difference was statistically significant(P<0.05).The total incidenceof adverse reactions 11.11%of the observation group was lower than that of the control group 28.89%,and the difference was statistically significant(P<0.05).Conclusion Drospirenone ethinylestradiol tablets combined with metformin is safe and effective in clinical treatment of PCOS,and it can significantly improve ovarian function.It is worthy of clinical promotion and application.