重组人干扰素对手足口病患儿临床疗效的影响

Effect of recombinant human interferon on the clinical efficacy of children with hand-foot-and-mouth disease

目的:观察雾化吸入重组人干扰素α-2b注射液对手足口病(HFMD)患儿的临床疗效及细胞因子的影响。方法:选取2017年5月至2019年5月于辽宁省锦州市中心医院就诊的HFMD患儿128例,随机分为干扰素组和对照组,每组64例。对照组接受常规治疗。干扰素组在常规对症治疗基础上接受重组人干扰素α-2b雾化吸入治疗。观察治疗前及治疗后3 d、5 d时,两组患儿体温、进食、口腔疱疹、皮疹改善情况,并测定血清中细胞因子的含量。结果:干扰素组总有效率(88.75%)高于对照组(73.89%)(P<0.05),干扰素组治疗后3 d、5 d内体温、手足皮疹、口腔疱疹改善情况优于对照组(P<0.05);两组患儿治疗后血清中白介素(IL)-4、IL-6、IL-10、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hsCRP)的含量均显著降低,且干扰素组血清中IL-4、IL-6、IL-10、TNF-α、hsCRP的含量均显著低于对照组(均P<0.05)。结论:雾化吸入重组人干扰素α-2b治疗HFMD能够改善免疫应答、减轻炎症反应,能有效促进患儿体温恢复及疱疹愈合,临床疗效较为满意。

Objective: To observe the clinical effect and cytokine effectof nebulized inhaledrecombinant human interferon α-2 b injection on children with hand-foot-and-mouth disease(HFMD).Methods: A total of 128 children with HFMD treated in ourhospital from May 2017 to May 2019 were selected and randomly divided into interferon group and control group, with 64 cases in each group. The control group was given routine treatment.The interferon group was givennebulizedinhaled recombinant human interferon α-2 b on the basis of routine symptomatic treatment. The improvement of body temperature, food intake, oral herpes, and skin rash were observed before the treatment and after 3 days and 5 days of treatment, and the content of cytokines in serum was detected.Results: The total effective rate in the interferon group(88.75%) was higher than that in the control group(73.89%)(P<0.05). The improvement of body temperature, hand-foot rash, and oral herpes in the interferon group werebetter than thosein the control group after 3 and 5 days of treatment(P<0.05). After treatment, the contents of serum interleukin-4(IL-4), interleukin-6(IL-6), interleukin-10(IL-10), tumor necrosis factor-α(TNF-α),and hypersensitive C-reactive protein(hsCRP) in twogroups were significantly decreased, and the serum contents of IL-4, IL-6, IL-10, TNF-α, and hsCRP in the interferon group were significantly lower than those in the control group(all P<0.05).Conclusion: Nebulizedinhaledrecombinant human interferon α-2 b in treatment of HFMD can improve the immune response, reduce inflammatory reactions, and effectively promote the recovery of body temperature and the healing of herpes. The clinical efficacy is satisfactory.