鼻咽癌患者治疗前后心理状态及淋巴细胞亚群变化的相关研究

Study on the Changes of Mental State and Lymphocyte Subsets in Patients with Nasopharyngeal Carcinoma Before and After Treatment

目的研究鼻咽癌患者治疗前后心理状态与免疫功能的相关性。方法回顾性分析50例鼻咽癌患者放化疗前后的心理痛苦评分及TBNK(淋巴细胞亚群)水平变化,通过二分类logistic回归模型分析影响心理痛苦的主要因素,同时探索心理状态与免疫功能的相关性。结果通过二分类logistic回归分析发现,分期、浅表淋巴结肿大是引起鼻咽癌患者心理痛苦的主要因素。治疗后心理痛苦评分较治疗前降低(P=0.000),差异有统计学意义。低心理痛苦评分组(4分以下)的患者CD3+CD4+水平较高(P=0.036),差异有统计学意义。结论鼻咽癌患者普遍存在心理痛苦状态。机体免疫功能受情绪影响,提高鼻咽癌病人的心理健康水平,可能有助于改善其免疫功能。

Objective To investigate the correlation between mental health status and immune function of patients with nasopharyngeal carcinoma(NPC)before and after treatment. Methods The changes of psychological distress score and TBNK lymphocyte subsets in 50 patients with NPC before and after radiotherapy and chemotherapy were analyzed retrospectively. The binary Logistic regression model was used to analyze the main factors of influencing psychological distress. At the same time, the correlation between mental state and immune function was explored. Results According to the binary logistic regression analysis, disease staging and positive signs(superficial lymph node swelling) were the main factors of psychological distress in patients with NPC. Psychological distress score after treatment was lower than that before treatment(P=0.000), and the difference was statistically significant.The level of CD3+ and CD4+was higher in the group with low psychological distress score(below 4 points)(P=0.036), and the difference was statistically significant. Conclusion Psychological distress is common in NPC patients. The immune function of the body is affected by emotion, which may help to improve the immune function of NPC patients.