胸腺五肽辅助治疗食管癌术后并发肺部感染的临床效果分析

Analysis of the clinical effect of thymopentin in adjuvant treatment of postoperative esophageal cancer complicated with pulmonary infection

目的探讨食管癌术后并发肺部感染患者使用胸腺五肽进行辅助治疗的临床效果。方法回顾性分析100例食管癌术后并发肺部感染患者的临床资料,50例常规治疗患者设为对照组,50例增加胸腺五肽辅助治疗患者设为观察组。对比两组C反应蛋白(CRP)、最高体温、白细胞数量和肺部病灶吸收情况。结果治疗第7天,两组最高体温均降低(P<0.01),观察组降低幅度大于对照组(P<0.01);治疗第5天,两组CRP水平均较第1天降低(P<0.01),观察组CRP水平低于对照组(P<0.01);治疗第7天,两组白细胞数量均低于治疗第1天(P<0.01);治疗第5、7天,观察组肺部病灶吸收率均高于对照组(P<0.05)。结论使用胸腺五肽对食管癌术后并发肺部感染患者进行辅助治疗效果显著,使用该药物可以降低炎症水平,促进患者康复,值得推广应用。

Objective To investigate the clinical effect of adjuvant treatment in patients with pulmonary infection after esophageal cancer surgery.Methods The clinical data of one hundred patients with postoperative esophageal cancer complicated with pulmonary infection were retrospectively analyzed,fifty patients with conventional treatment were set as the control group,and fifty patients with adjuvant thymopentin therapy were set as the observation group.The C-reactive protein(CRP),maximum body temperature,number of white blood cells,and absorption of lung lesions were compared between the two groups.Results On the 7 th day of treatment,the maximum body temperature of the two groups decreased(P<0.01),and the decrease in the observation group was greater than that of the control group(P<0.01);On the 5 th day of treatment,the CRP levels of the two groups were lower than that on the 1 st day(P<0.01),the CRP level of the observation group was lower than that of the control group(P<0.01);On the 7 th day of treatment,the number of white blood cells in the two groups was lower than that on the 1 st day of treatment(P<0.01);On the 5 th and 7 th day of treatment,the absorption rate of lung lesions in the observation group was higher than that in the control group(P<0.05).ConclusionThe use of thymopentin for adjuvant treatment of patients with pulmonary infection after esophageal cancer surgery has a significant effect.The use of this drug can reduce the level of inflammation and promote the recovery of patients.It is worthy of promotion and application.