乙基丹皮酚肟氨基己基醚的合成及表征

Synthesis and Characterization of Ethylpaeonoxime Aminohexyl Et her

目的:合成乙基丹皮酚肟氨基己基醚并优化其合成工艺.方法:以丹皮酚为原料,在碱性条件下与溴乙烷反应得到乙基丹皮酚醚,再将乙基丹皮酚醚的酮羰基与盐酸羟胺发生缩合生成乙基丹皮酚肟,然后其肟羟基与1,6-二溴己烷进行亲核取代,生成乙基丹皮酚肟溴代己基醚,再与N-乙基哌嗪反应生成了乙基丹皮酚肟氨基己基醚.结果和结论:目标化合物结构经1H-NMR,MS, IR等确证.

Objective:Synthesis of ethyl paeonoxime aminohexyl ether and optimization of its synthesis process.Methods:the ethyl paeonol ether was obtained by the reaction of paeonol with bromoethane in basic condition.The ketone carbonyl group of the ethyl paeonol ether was condensed with hydroxylamine hydrochloride to produce ethyl paeonol oxime,then the oxime hydroxyl group and 1,6-dibromohexane was nucleophilic substituted to form ethyl paeonoxime bromohexyl ether,and then reacted with N-ethyl piperazine to form ethyl paeonoxime aminohexyl ether.Results and conclusion:the structure of the target comp ound was confirmed by 1H-NMR,MS and IR.