三阴性乳腺癌的治疗进展

Progress in treatment of triple negative breast cancer

目的总结近年来三阴性乳腺癌(TNBC)基于基因治疗、免疫治疗、靶向治疗等方面综合治疗的研究进展,以期提高对该病的认识和治疗水平。方法检索国内外近5年来关于TNBC治疗的相关文献并进行分析总结。结果 TNBC因其治疗缺乏靶向受体,较其他分型的乳腺癌侵袭性强、复发转移早,治疗方案目前仍为手术治疗为主,辅以化疗、放疗等的综合治疗。结论虽然近年来TNBC在手术治疗、放化疗、靶向治疗等方面的研究均显示出不错的临床应用前景,但目前仍需要更多大样本的临床试验证据。随着分子机制研究的不断深入,包括雄激素受体阳性的内分泌治疗、靶向药物治疗等为TNBC的治疗提供了一些新的想法。

Objective To summarize research progress of comprehensive treatment based on gene therapy,immunotherapy,and targeted therapy in recent years in order to improve understanding and treatment level of triple negative breast cancer(TNBC).Method The literatures about TNBC treatment in recent 5 years were reviewed and summarized.Results TNBC was more invasive than other types of breast cancer due to its lack of targeted receptors,and its recurrence and metastasis were earlier.The treatment plan was still mainly surgical treatment,supplemented by the chemotherapy and radiotherapy.Conclusions Although recent studies of TNBC in surgical treatment,chemoradiotherapy,targeted therapy and other aspects have shown a good clinical application prospect,more evidences of clinical trials with large samples are still needed.With the deepening of molecular mechanism research,endocrine therapy and targeted drug therapy,including androgen-receptor-positive,have provided some new ideas for treatment of TNBC.