结合珠蛋白作为急性脑梗死患者预后标志物的研究

Haptoglobin level as a prognostic marker for patients with acute cerebral infarction

目的探讨血浆结合珠蛋白(Hp)水平在急性脑梗死患者预后判断中的临床价值。方法收集2013年1月至2014年12月在该院接受治疗的急性脑梗死患者100例(病例组)和100例体检健康者(对照组)。采用ROC曲线和Kaplan-Meier法评估血浆Hp预测急性脑梗死预后的价值。结果病例组中吸烟者、糖尿病者、高血压者、心绞痛者、血浆Hp显著高于对照组(P<0.05)。血浆Hp预测急性脑梗死患者3年死亡事件发生的最佳截断值为275.25μg/L。血浆Hp≥275.25μg/L组高血压者、心肌梗死者、Hp2-1表型数、血浆Hp浓度、3年总死亡率均高于血浆Hp<275.25μg/L组(P<0.05)。但Hp1-1表型数显著低于血浆Hp<275.25μg/L组(P<0.05)。血浆Hp≥275.25μg/L组患者3年总死亡率显著高于血浆Hp<275.25μg/L组(P<0.05)。结论血浆Hp水平高的患者3年总死亡率显著偏高,血浆Hp水平有可能成为预测急性脑梗死患者预后的生物学标志物。

Objective To investigate the clinical value of plasma haptoglobin(Hp)level as a prognostic marker for patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction who were treated in our hospital from January 2013 to December 2014 were enrolled as case group,and 100 healthy individuals who underwent physical examination were enrolled as control group.The receiver operating characteristic(ROC)curve and the Kaplan-Meier method were used to evaluate the value of plasma Hp in predicting the prognosis of patients with acute cerebral infarction.Results Compared with the control group,the case group had a significantly higher proportion of patients with smoking,diabetes,hypertension or angina pectoris and a significantly higher plasma Hp level(P<0.05).Plasma Hp had a cut-off value of 275.25μg/L in predicting 3-year death in patients with acute cerebral infarction.Compared with the plasma Hp<275.25μg/L group,the plasma Hp≥275.25μg/L group had a significantly higher proportion of patients with hypertension,myocardial infarction,or Hp2-1(P<0.05),a significantly lower proportion of patients with Hp1-1(P<0.05),and significantly higher plasma Hp level and 3-year overall mortality rate(P<0.05).Conclusions Patients with a higher plasma Hp level tend to have a relatively high 3-year overall mortality rate,and plasma Hp level can be used as an important biomarker to predict the prognosis of patients with acute cerebral infarction.