初诊广泛性焦虑障碍患者血浆GDNF、NPY、Cor水平与记忆功能的相关性

Correlation study between plasma levels of GDNF,NPY,Cor and memory function in patients with first-episode generalized anxiety disorder

目的探讨初诊广泛性焦虑障碍(GAD)患者血浆胶质细胞源性生长因子(GDNF)、神经肽Y(NPY)、皮质醇(Cor)水平和记忆功能的相关性。方法84例初诊GAD患者纳入GAD组,并依据不同焦虑程度分为轻度焦虑组(28例)、中度焦虑组(35例)及重度焦虑组(21例),选择同期79例健康者纳入对照组。比较各组血浆GDNF、NPY、Cor水平和记忆功能指标,并分析各血浆指标和记忆功能指标的相关性。结果GAD组Cor、总延迟反应时间、无延迟反应时间高于对照组,GDNF、NPY、总延迟正确数、无延迟正确数低于对照组,差异有统计学意义(P<0.05)。重度焦虑组Cor、总延迟反应时间、无延迟反应时间高于中度焦虑组及轻度焦虑组,GDNF、NPY、总延迟正确数、无延迟正确数低于中度焦虑组及轻度焦虑组,差异有统计学意义(P<0.05)。GDNF、NPY与总延迟正确数、无延迟正确数呈正相关,与总延迟反应时间、无延迟反应时间呈负相关(P<0.05);Cor与总延迟正确数、无延迟正确数呈负相关(P<0.05),与总延迟反应时间、无延迟反应时间呈正相关(P<0.05)。结论血浆GDNF、NPY、Cor水平与初诊GAD的焦虑程度、记忆功能相关,其水平的检测有望用于诊断GAD,但需大样本的研究进一步证实。

Objective To study the correlation between plasma glial cell-derived growth factor(GDNF),neuropeptide Y(NPY),cortisol(Cor)and memory function in patients with first-episode generalized anxiety disorder(GAD).Methods A total of 84 patients with first-episode for GAD were recruited into study group,and divided into moderate anxiety group(28 cases),mild anxiety group(35 cases)and severe anxiety group(21 cases)according to different anxiety levels,and 79 healthy patients were selected into control group at the same time.The levels of GDNF,NPY,Cor and memory function indexes in each group were compared,and the correlations between plasma indexes and memory function indexes were analyzed.Results Cor,total delayed reaction time and non-delayed reaction time in GAD group were higher than those in control group,GDNF,NPY,total delayed correct number and non-delayed correct number in GAD group were lower than those in control group(P<0.05).The Cor,total delay reaction time,no delay reaction time in severe anxiety group were higher than those in moderate anxiety group and mild anxiety group,while GDNF,NPY,total delayed correct number and non-delayed correct number were lower than those in moderate anxiety group and mild anxiety group(P<0.05).GDNF and NPY correlated positively with total delayed correct number and non-delayed correct number,correlated negatively with total delay reaction time,no delay reaction time(P<0.05).Cor correlated negatively with total delayed correct number and non-delayed correct number,and correlated positively with total delay reaction time,no delay reaction time(P<0.05).Conclusion Plasma GDNF,NPY and Cor levels relate to anxiety and memory function of first-episode GAD,detection the levels of these indicators might be useful for diagnosis of first-episode GAD,but further study on large samples is needed.