牡蛎酶解产物促进皮肤软组织创伤愈合的作用

Effect of enzymolysis products of oyster on wound healing of skin

通过动物实验,比较牡蛎酶解产物低、中、高3个灌胃剂量组与2个对照组在皮肤创伤愈合过程中的照片、创伤愈合率、瘢痕缩小率、IL-6、IL-10和TGF-β等指标。结果显示:第6、10天低、高剂量组创伤愈合率均高于两个对照组(P<0.05),第14天,低、高剂量组的愈合率较阴性对照组显著提高(P<0.05);牡蛎酶解产物能够有效抑制炎症因子IL-6生成,并促进IL-10分泌(P<0.05);低剂量组FGF-2含量高于其他组,但无显著性差异(P>0.05),与阴性对照组TGF-β含量相比,其他组皆呈现显著差异(P<0.05),3个剂量组CCND1含量皆显著高于2个对照组(P<0.05),低、高剂量组EGF含量显著高于其他组(P<0.05);第7天低剂量组羟脯氨酸含量较阴性对照组显著提高(P<0.05),第14天,各给药组均能显著提高皮肤组织中的羟脯氨酸含量且低剂量组提高了瘢痕缩小率(P<0.05)。牡蛎酶解产物能够加快小鼠软组织开放性创伤愈合,对浅表瘢痕增生具有一定的抑制作用。

We compared photos,wound healing rate,scar reduction rate,IL-6,IL-10,TGF-β,etc.in the skin wound healing process of the groups of IG low,medium and high dose enzymolysis products of oyster by animal experiment,and the results are shown as follows:The wound healing rate of the low and high dose groups was higher than that of the two control groups at 6 and 10 days and on the 14 th day the healing rate of the low and high dose groups was significantly higher than that of the negative control group(P<0.05);Enzymolysis products of oyster can inhibit the production of inflammatory factor IL-6 and promote IL-10 secretion(P<0.05);The FGF-2 content in the low dose group was higher than the other groups but there was no significant difference(P>0.05),compared with the TGF-βcontent in the negative control group(P<0.05),the levels of CCND1 in the three dose groups were significantly higher than the two control groups(P>0.05),and the EGF content in the low and high dose groups was significantly higher than that in the other groups(P>0.05);On the 7 th day the hydroxyproline content in the low dose group was significantly higher than that in the negative control group(P<0.05),and on the 14 th day the hydroxyproline content in the skin tissue was significantly increased in each administration group and low dose group improves scar contraction rate(P<0.05).Enzymolysis products of oyster has accelerated wound healing of soft tissue in mice and has a certain inhibitory effect on superficial scar hyperplasia.