筛状成分在肺腺癌中的研究进展

Progress in Research on the Cribriform Component in Lung Adenocarcinoma

肺癌是全世界发病率最高的恶性肿瘤。目前,肺腺癌(lung adenocarcinoma,LUAD)是肺癌中最常见的组织学类型。然而,具有相同病理亚型的LUAD患者之间却存在显著的预后差异,导致该预后差异的主要原因之一是其组织学异质性。研究表明,除了2015年世界卫生组织(World Health Organization,WHO)对浸润性LUAD的5种主要生长方式的分类外,LUAD中还存在其他的组织学结构并影响其临床预后。其中,筛状成分(cribriform component,CC)是当前LUAD病理组织学的研究热点之一。已有研究表明,CC的有无可进一步预测LUAD患者的预后。随着相关研究逐渐深入,CC与LUAD各组织学类型、临床病理因素、生存预后等方面的关联尚存在争议。本文综合论述了CC在LUAD中的研究进展。

The morbidity of lung cancer ranks top in the world.At present,lung adenocarcinoma(LUAD)is the most common histologic type of lung cancer.However,the prognoses of LUAD patients with the same subtype remain heterogeneous.Histological heterogeneity is one of the main causes of diverse prognoses of patients with LUAD.Studies have shown that there are other histologic patterns that affect the clinical outcomes of LUAD patients,in addition to the five growth patterns of invasive LUAD classified by the World Health Organization(WHO)in 2015.The cribriform component(CC)is one of the research hotspots among histopathology of LUAD.Previous studies have shown that the presence of CC can further stratify the prognoses of patients with LUAD.Along with the progressively deep insights into the aforementioned topic,researchers are dedicating to unveiling the relationships among CC and and other clinicopathological factors as well as their joint influence on the survival of LUAD patients.The review manages to generalize the latest research progress in the CC in LUAD patients.