摘要
Bicyclo[1.1.1]pentane (BCP) scaffolds can serve as bioisosteres of phenyl, tert-butyl and alkyne groups which are widely used in medicinal chemistry today [1]. Replacing para-phenyl rings in most of pharmaceutical candidates with 1,3-disubstituted BCP moieties will improve their biological activities and physico-chemical profiles[2].
作者
Fen Tan
You-Quan Zou
谭芬;邹有全(Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients,Hubei University of Education,Wuhan 430205,China;Department of Chemistry,University of Cambridge,Cambridge CB21EW,UK)
基金
the National Natural Science Foundation of China (21602052)。
