二肽基肽酶4抑制剂对心血管保护作用的研究现状

Current status of research on cardiovascular protective effect of dipeptidyl peptidase 4 inhibitor

二肽基肽酶4(DPP-4)抑制剂是应用于2型糖尿病的新型口服降糖药物,通过抑制DPP-4的活性减少内源性胰高血糖素样肽1(GLP-1)的降解来增强胰岛素分泌,从而发挥降糖作用.有研究表明,DPP-4抑制剂通过多种机制发挥潜在的心血管保护作用,本文将结合基础和临床的相关研究结果,对DPP-4抑制剂对心血管的保护作用及机制进行综述.

Dipeptidyl peptidase 4(DPP4)inhibitor is a novel oral hypoglycemic agent for type 2 diabetes mellitus,which reduces the degradation of endogenous glucagon-like peptide 1(GLP-1)by inhibiting the activity of DPP4,enhances insulin secretion,thereby exerting hypoglycemic effect.Studies have indicated that DPP-4 inhibitors exert potential cardiovascular protection through a variety of mechanisms.The present article will combine the basic and clinical re lated research results to review cardiovascular protection and mechanism of DPP4-inhibitors.