不同激素应用方案下肉芽肿乳腺炎症妇女的疗效与安全性对比

Comparison of the efficacy and safety of granulomatous mastitis in women under different hormonal application regimens

〔目的〕探究不同激素应用方案下肉芽肿乳腺炎症(GM)妇女的疗效与安全性,为肉芽肿乳腺炎症患者的治疗与预后提供参考。〔方法〕选取2016年6月至2018年6月某医院收治的GM患者246例,根据不同激素应用方案将所有患者分为疼痛用药组(n=109)、冲击用药组(n=46)、持续用药组(n=42)及指标用药组(n=49)。观察并比较各组患者手术中切除腺体量及出血量、手术后引流液变淡时间及引流量、术后1年复发情况及不良反应发生情况。〔结果〕各组患者术中切除腺体量及出血量、术后引流液变淡时间及引流量、术后1年内复发率比较差异均没有统计学意义(P>0.05);与持续用药组指标用药组相比,疼痛用药组及冲击用药组患者不良反应发生率较低,比较差异有统计学意义(P<0.05);疼痛用药组患者不良反应发生率明显高于冲击用药组,差异具有统计学意义(P<0.05)。〔结论〕在GM患者的治疗中增加激素类药物药量不能达到提高治疗效果及预后的目的,大剂量使用激素类药物在短时间内行冲击治疗,有利于降低患者不良反应的发生率。

〔Objective〕To explore the efficacy and safety of granulomatous mastitis in women under different hormonal regimens,to provide reference for clinical treatment and prognosis of patients with granulomatous mastitis.〔Methods〕246 patients with granulomatous breast inflammation admitted to a hospital from June 2016 to June 2018 were selected,according to different hormone application programs,all patients were divided into pain medication group(n=109),impact medication group(n=46),continuous medication group(n=42)and index medication group(n=49).The surgical removal of gland volume and bleeding volume,the time of postoperative drainage fluid dilution and drainage volume,one year postoperative recurrence,and the incidence of adverse reactions in each group of patients were observed and compared.〔Results〕There was no statistically significant difference in the surgical removal of gland volume and blood loss during operation,the time of postoperative drainage fluid dilution and drainage volume,and the recurrence rate within one year after surgery in each group(P>0.05);compared with the continuous medication group and the index medication group,the incidence of adverse reactions was lower in the pain medication group and the impact medication group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the pain medication group was significantly higher than that in the impact medication group,the difference was statistically significant(P<0.05).〔Conclusion〕Increasing the dosage of hormone drugs in the treatment of GM patients can t achieve the purpose of improving the therapeutic effect and prognosis,but high-dose hormonal drugs are used for pulse therapy in the short time,which is helpful to reduce the incidence of adverse reactions in patients.