铝碳酸镁联合兰索拉唑治疗胃溃疡效果观察

Effect of combination of magnesium aluminum carbonate and lansoprazole sodium in the treatment of gastric ulcer

目的探讨铝碳酸镁联合兰索拉唑钠治疗胃溃疡的临床效果。方法选取杭州市大江东医院2017年10月至2018年10月收治的胃溃疡患者100例为观察对象,采用随机数字表法分为对照组和观察组,每组50例。对照组采用常规三联疗法治疗,观察组采用铝碳酸镁联合兰索拉唑钠胶囊治疗,两组疗程均为8周。观察两组疗效。结果观察组总有效率为96.0%(48/50),高于对照组的70.0%(35/50),差异有统计学意义(χ^2=12.428,P<0.01);治疗后,观察组胃动素、胃泌素、胶原纤维面积百分数、中性黏液面积百分数分别为(255.22±36.29)ng/L、(142.19±9.86)μg/L、(46.29±5.27)%、(55.29±6.82)%,均优于对照组的(281.73±30.84)ng/L、(114.58±8.35)μg/L、(35.69±4.38)%、(36.75±5.23)%,均差异有统计学意义(t=36.582、31.125、12.785、21.745,均P<0.05);观察组腹痛、嗳气、反酸、腹胀积分分别为(1.46±0.52)分、(0.35±0.05)分、(0.49±0.13)分、(1.38±0.23)分,均低于对照组的(2.58±0.41)分、(1.46±0.71)分、(1.28±0.54)分、(2.65±0.48)分(t=1.836、1.485、1.023、1.258,均P<0.05);观察组不良反应发生率为4.0%(2/50),低于对照组的30.0%(15/50)(χ^2=14.258,P<0.01)。结论铝碳酸镁联合兰索拉唑钠治疗胃溃疡有较好的临床效果,优于常规三联疗法。

Objective To investigate the clinical effect of combination of aluminum magnesium carbonate and lansoprazole sodium in the treatment of gastric ulcer.Methods From October 2017 to October 2018,100 patients with gastric ulcer in Hangzhou Dajiangdong Hospital were randomly divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with routine triple therapy,and the observation group was treated with aluminum magnesium carbonate combined with lansoprazole sodium capsule.The course of treatment in both two groups was eight weeks.The curative effect of the two groups was observed.Results The total effective rate of the observation group was 96.0%(48/50),which was higher than that of the control group[70.0%(35/50)],the difference was statistically significant(χ^2=12.428,P<0.01).After treatment,the motilin,gastrin,percentages of collagen fiber area and neutral mucus area in the observation group were(255.22±36.29)ng/L,(142.19±9.86)μg/L,(46.29±5.27)%,(55.29±6.82)%,respectively,which were better than those in the control group[(281.73±30.84)ng/L,(114.58±8.35)μg/L,(35.69±4.38)%,(36.75±5.23)%],the differences were statistically significant(t=36.582,31.125,12.785,21.745,all P<0.05).The scores of abdominal pain,belching,acid regurgitation and abdominal distension in the observation group were(1.46±0.52)points,(0.35±0.05)points,(0.49±0.13)points and(1.38±0.23)points,respectively,which were lower than those in the control group[(2.58±0.41)points,(1.46±0.71)points,(1.28±0.54)points and(2.65±0.48)points](t=1.836,1.485,1.023,1.258,all P<0.05).The incidence of adverse reactions in the observation group[4.0%(2/50)]was lower than that in the control group[30.0%(15/50)](χ^2=14.258,P<0.01).Conclusion The combination of magnesium aluminum carbonate and lansoprazole sodium has good clinical effect on gastric ulcer,which is superior to the conventional triple therapy.