益气养精方联合中药贴敷治疗肺癌癌性胸水34例

Clinical study on treatment of lung cancer hydrothorax with Yiqi Yangjing decoction combined with traditional Chinese medicine sticking therapy

目的观察益气养精方联合贴敷疗法治疗肺癌癌性胸水的临床疗效。方法选取上海市浦东新区中医医院2017年12月至2019年8月收治的肺癌癌性胸水患者68例为研究对象,采用随机数字表法分为对照组、治疗组各34例,对照组在常规营养支持治疗的基础上予呋塞米口服,治疗组在对照组的基础上予益气养精方口服及中药贴敷治疗。两组疗程均为6周。观察并比较两组患者胸水量及生存质量评分变化。结果治疗组胸水改善总有效率为70.5%(24/34),对照组为47.1%(16/34),两组差异有统计学意义(χ^2=3.886,P<0.05)。治疗组中医证候积分总有效率为64.7%(22/34),对照组为35.3%(12/34),两组差异有统计学意义(χ^2=5.800,P<0.05)。治疗后,治疗组整体生活质量评分为(55.74±5.15)分,高于对照组的(51.91±5.20)分(t=56.130,P<0.05)。结论益气养精方联合中药贴敷疗法可有效提高肺癌癌性胸水的临床疗效,提高患者生存质量。

Objective To observe the clinical effect of Yiqi Yangjing recipe combined with sticking therapy on lung cancer pleural effusion.Methods From December 2017 to August 2019,68 patients with advanced lung cancer and pleural effusion in Pudong New Area Hospital of Traditional Chinese Medicine were selected and randomly divided into two groups by random number table method,with 34 cases in each group.The control group was given furosemide orally on the basis of routine nutritional support treatment,and the treatment group was given Yiqi Yangjing prescription orally and traditional Chinese medicine sticking therapy on the basis of the control group.Both two groups were treated for 6 weeks.The changes of pleural fluid volume and quality of life scores were observed and compared between the two groups.Results The total effective rate in the treatment group was 70.5%(24/34),which in the control group was 47.1%(16/34),the difference was statistically significant between the two groups(χ^2=3.886,P<0.05).The total effective rate of TCM syndrome integral was 64.7%(22/34)in the treatment group,and 35.3%(12/34)in the control group,the difference was statistically significant between the two groups(χ^2=5.800,P<0.05).After treatment,the overall quality of life score of the treatment group(55.74±5.15)points,which was higher than that of the control group[(51.91±5.20)points](t=56.130,P<0.05).Conclusion Yiqi Yangjing recipe combined with traditional Chinese medicine sticking therapy can effectively improve the clinical efficacy of lung cancer hydrothorax,improve the quality of life of patients.