胃轻瘫消化内镜治疗应用进展

Application progress of digestive endoscopy for gastric emptying disorders

胃轻瘫是一种胃运动障碍性疾病,主要表现为恶心呕吐、餐后早饱及腹痛腹胀等消化不良症状。药物治疗主要有促进胃动力药物如甲氧氯普胺、多潘立酮等。多数患者早期对药物反应良好,部分患者出现药物难治性症状。基于胃轻瘫发病机制及消化内镜技术发展,目前对于药物难治性胃轻瘫治疗方式有胃电刺激、幽门内注射肉毒素、幽门支架、经口内镜下幽门切开术等。本文将简述胃轻瘫内镜辅助治疗方式的研究进展。

Gastroparesis is a neuromuscular disease characterized by nausea and vomiting,early postprandial satiety,abdominal pain and distention.Drug therapy mainly includes gastric motility drugs such as metoclopramide and domperidone.Most patients responded well to drugs in the early stage,and some patients developed severe drug-resistant symptoms.Based on the pathogenesis of gastroparesis and the development of endoscopy technology,the current treatment methods for drug-refractory gastroparesis include gastric electrical stimulation,botulinum toxin injection,pyloric stent,gastric per-oral endoscopic pyloromyotomy,etc.This article will briefly describe the endoscopy-assisted treatment of gastroparesis.