骨骼肌通过力学刺激对骨重建的影响

Effects of Skeletal Muscle on Bone Remodeling through Mechanical Stimulation

骨骼与骨骼肌作为运动系统最重要的组织,两者之间存在密切的联系。骨肌单元的概念提出已久,运动产生的力学负荷将两者紧密地联系在一起。骨骼为骨骼肌施力提供力学支撑,而骨骼肌收缩带动机体的运动。在机体运动过程中,骨骼肌充当力学负荷与骨骼之间的中间媒介,并通过内分泌因子以及力学信号调节骨骼的代谢活动,与机体内持续不断的骨重建密切相关,并维持骨骼良好的结构和功能。主要综述近年来骨骼肌通过对骨骼施加力学刺激影响骨重建作用的研究进展,为预防和治疗骨代谢疾病提供新的思路。

As the most important tissues of the motor system,skeleton and skeletal muscles are closely related to each other.The concept of bone-muscle units has been proposed for a long time,and they are linked closely by mechanical loading generated by exercise.Skeleton provides mechanical support attachments for skeletal muscle force,and contraction of skeletal muscle drives body movement.During the process of body movement,acting as an intermediate medium between the mechanical load and bone,skeletal muscles regulate metabolic activity of the bone through endocrine factors and mechanical stimulation,which is closely related to continuous bone remodeling and maintains good structure and function of the bone.This review focuses on recent research progress of skeletal muscle affecting bone remodeling by applying mechanical stimulation to the bone,which will provide some new ideas for prevention and treatment of bone metabolism diseases.