妇炎平胶囊联合奥硝唑栓治疗老年细菌性阴道炎的临床研究

Clinical study on Fuyanping Capsules combined with Ornidazole Suppositories in treatment of senile bacterial vaginitis

目的分析妇炎平胶囊联合奥硝唑栓治疗老年细菌性阴道炎的临床效果。方法选择2017年3月—2019年2月在南阳市卧龙区妇幼保健院治疗的老年细菌性阴道炎患者157例,随机分为对照组(78例)和治疗组(79例)。对照组患者睡前阴道置入奥硝唑栓,1粒/次,1次/d;治疗组在对照组基础上睡前阴道置入妇炎平胶囊,2粒/次,1次/d。两组患者均连续用药10 d。观察两组患者临床疗效,同时比较治疗前后两组患者血清白细胞介素IL-8(IL-8)、IL-6和IL-2水平,以及临床症状消失时间。结果治疗后,对照组和治疗组临床有效率分别为78.21%和93.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清IL-8、IL-6和IL-2水平均显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,治疗组患者阴道疼痛消失时间、白带减少时间、黏膜充血消失时间和外阴瘙痒消失时间均明显比对照组早(P<0.05)。结论妇炎平胶囊联合奥硝唑栓治疗老年细菌性阴道炎,可快速改善患者阴道疼痛、外阴瘙痒等临床症状,改善机体炎症反应状况,临床疗效较好。

Objective To analyze the clinical effect of Fuyanping Capsules combined with Ornidazole Suppositories in treatment of senile bacterial vaginitis.Methods Patients(157 cases)with senile bacterial vaginitis in Nanyang Wolong District Maternal and Child Health Hospital from March 2017 to February 2019 were randomly divided into control(78 cases)and treatment(79 cases)groups.Patients in the control group were vaginally implanted administered with Ornidazole Suppositories before bed,1 garin/time,once daily.Patients in the treatment group were vaginally implanted administered with Fuyanping Capsules before bed on the basis of the control group,2 grains/time,once daily.Patients in two groups were treated for 10 d.After treatment,the clinical efficacy was evaluated,and the serum level of IL-8,IL-6 and IL-2,and the disappearance time of clinical symptom in two groups before and after treatment were compared.Results After treatment,the clinical efficacy and in the control and treatment groups was 78.21%and 93.67%respectively,and there were differences between two groups(P<0.05).After treatment,the serum level of IL-8,IL-6 and IL-2 in two groups was significantly decreased(P<0.05),and which in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the dsappearance time of vaginal pain,mucosal congestion and vulvar pruritus,the time of leucorrhea reduced in the treatment group was significantly earlier than that in the control group(P<0.05).Conclusion Fuyanping Capsules combined with Ornidazole Suppositories in treatment of senile bacterial vaginitis can rapidly improve the vaginal pain and vulvar pruritus,and improve the inflammatory response,and which has good clinical effect.