参芎葡萄糖注射液致大疱性表皮松解症

Epidermolysis bollosa induced by salivae miltiorrhizae,liguspyragine hydrochloride and glucose injection

1例75岁男性患者因脑梗死给予参芎葡萄糖注射液200 ml静脉滴注、1次/d,同期未使用其他药物。首次用药约6 h后,患者全身出现红斑、水疱,伴明显瘙痒;次日出现发热,大片肿胀性红斑上可见大小不等的水疱,部分水疱破溃,皮损面积超过50%,尼氏征阳性。考虑为参芎葡萄糖注射液导致的大疱性表皮松解症。停用该药,给予甲泼尼龙、葡萄糖酸钙、氯雷他定、头孢唑啉钠等抗过敏和抗感染治疗,同时加强皮肤护理。3 d后患者体温恢复正常,红斑颜色变淡,水疱变小。15 d后皮肤损伤基本愈合。

A 75⁃year⁃old male patient received an IV infusion of salivae miltiorrhizae,liguspyragine hydrochloride and glucose injection 200 ml once daily for cerebral infarction.No other drugs were used in the same period.About 6 hours after the first administration,the patient developed erythema and blister all over the body,accompanied by obvious itching.Next day,the patient had a fever,blisters of different sizes could be seen on a large area of swollen erythema,some of the blisters were broken,the area of skin lesions was more than 50%of the body surface,and Nikolsky′s sign was positive.Epidermolysis bullosa caused by salivae miltiorrhizae,liguspyragine hydrochloride and glucose injection was considered.The drug was stopped and anti⁃allergy and anti⁃infection treatments including methylprednisolone,calcium gluconate,loratadine,and cefazolin sodium were given.Meanwhile,skin care was strengthened.Three days later,the patient′s body temperature returned to normal,the color of erythema became lighter,and the blisters became smaller.Fifteen days later,the patient′s skin injury basically healed.