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中药穴位贴敷辅助治疗小儿支原体肺炎痰热闭肺型47例临床观察 被引量:11

Clinical observation on 47 cases of mycoplasmal pneumoniae pneumonia in children with phlegm-heat blocking lung type treated by acupoint application of Chinese materia medica as adjuvant therapy
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摘要 目的观察中药穴位贴敷辅助治疗小儿支原体肺炎(MPP)痰热闭肺型的临床疗效。方法选取2017年2月至2018年2月于南京市中西医结合医院儿科收治的MPP痰热闭肺型患儿94例,按照随机数字表法分为治疗组和对照组,各47例。2组均予MPP常规治疗,对照组加用布地奈德雾化吸入治疗,治疗组在对照组治疗方法的基础上加用自制中药方穴位贴敷治疗。2组均连续治疗14 d并随访1个月后比较2组的临床疗效、复发情况,检测2组治疗前后血清炎性因子及免疫球蛋白水平。结果治疗前,2组IgA、IgG、IgM水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标均明显升高,与同组治疗前比较,差异均有统计学意义(P<0.01),且治疗组升高更显著(P<0.05)。治疗前,2组白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、γ干扰素(IFN-γ)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标均明显下降,与同组治疗前比较,差异均有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。对照组总有效率为77.73%(37/47),治疗组为95.74%(45/47),2组比较,差异有统计学意义(P<0.05)。随访1个月后,对照组复发率为29.70%(11/37),治疗组为4.44%(2/45),2组比较,差异有统计学意义(P<0.05)。结论中药穴位贴敷辅助治疗小儿MPP痰热闭肺型疗效确切,能够有效改善机体炎症状态,提高患儿免疫功能,且复发率低,值得临床推广应用。 Objective To observe the clinical efficacy of acupoint application of Chinese materia medica in adjuvant treatment of mycoplasmal pneumonia pneumonia(MPP)in children with phlegm-heat blocking lung type.Methods From February 2017 to February 2018,94 cases of MPP with phlegm-heat blocking lung type admitted to pediatrics department in Nanjing Integrated Traditional Chinese and Western Medicine Hospital were divided into treatment group and control group according to random number table method,with 47 cases in each.Both groups were given MPP routine treatment,on this basis,the control group was added with budesonide aerosol inhalation,and the treatment group was added with self-made acupoint application of Chinese materia medica formula on the basis of the treatment of the control group.The 2 groups were both consecutively treated for 14 days and followed up for 1 month.The clinical efficacy and recurrence of the two groups were compared,and the levels of serum inflammatory factors and immunoglobulin before and after treatment of the 2 groups were detected.Results Before treatment,the difference was not statistically significant in the levels of IgA,IgG and IgM between the 2 groups(P>0.05),and they were comparable.After treatment,the above-mentioned indexes of the 2 groups all significantly increased,and the difference was statistically significant compared with the same group before treatment(P<0.01),moreover,the treatment group increased more significantly(P<0.05).Before treatment,the difference was not statistically significant in the levels of interleukin(IL)-2,IL-4,tumor necrosis factor(TNF)-α,and interferon(IFN)-γ(P>0.05),and they were comparable.After treatment,the above-mentioned indexes in the 2 groups all significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.01),moreover,the treatment group decreased more significantly(P<0.05).The total effective rate of the control group was 77.73%(37/47),that of the treatment group was 95.74%(45/47),and the difference between the 2 groups was statistically significant(P<0.05).After follow-up for 1 month,the recurrence rate of the control group was 29.70%(11/37),that of the treatment group was 4.44%(2/45),and the difference between the 2 groups was statistically significant(P<0.05).Conclusion It has definite effects,can effectively improve the inflammatory state of the body,improve the immune function of children and has low recurrence rate to use acupoint application of Chinese materia medica in adjuvant treatment of MPP in children with phlegm-heat blocking lung type,which is worthy of clinical promotion and application.
作者 程皓 王叶芳 CHENG Hao;WANG Yefang(Department of Pediatrics,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing,Jiangsu,210000,China)
出处 《中医儿科杂志》 2020年第4期68-71,共4页 Journal of Pediatrics of Traditional Chinese Medicine
关键词 小儿支原体肺炎 中药穴位贴敷 布地奈德 临床观察 mycoplasmal pneumonia pneumonia(MPP)in children acupoint application of Chinese materia medica budesonide clinical observation
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