摘要
半乳糖凝集素-3属于半乳糖凝集素家族,是一种广泛分布于人体内的内源性β-半乳糖苷结合凝集素,在细胞的增殖、分化、凋亡、细胞黏附、免疫反应以及信号转导等多种功能中发挥重要作用。越来越多的证据表明,半乳糖凝集素-3参与了呼吸系统多种疾病的发生发展,涉及特发性肺纤维化、肺癌、肺动脉高压和支气管哮喘等疾病。本综述总结并分析了半乳糖凝集素-3在以上几种呼吸系统疾病中的研究进展,以阐明其在呼吸系统疾病中的作用及机制,希望为临床治疗提供新的思路。
Galectin-3 is an endogenousβ-galactoside-binding lectin widely distributed in the human body,and it plays an important role in various functions such as cell proliferation,differentiation,apoptosis,cell adhesion,immune response and signal transduction.Accumulating evidence has shown that galectin-3 is involved in the occurrence and development of respiratory diseases,including idiopathic pulmonary fibrosis,lung cancer,pulmonary hypertension and bronchial asthma.This review summarizes and analyzes the research progress on galectin-3 in the above respiratory diseases in order to clarify its role and mechanism,and to provide new ideas for clinical treatment.
作者
司绒
程明涵
高建
SI Rong;CHENG Ming-han;GAO Jian(The Second Affiliated Hospital,School of Pharmacy,Dalian Medical University,Dalian 116023,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第7期1401-1409,共9页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81973637,81473267,81274172)。
关键词
半乳糖凝集素-3
特发性肺纤维化
肺癌
肺动脉高压
支气管哮喘
galectin-3
idiopathic pulmonary fibrosis
lung cancer
pulmonary arterial hypertension
bronchial asthma
