金属有机框架在生物医药领域的研究进展

Recent advances of metal-organic frameworks applied in biomedicine

金属有机框架(metal-organic frameworks,MOFs)是由有机配体与金属离子通过配位键形成的多孔结晶性聚合物,具有可调控的周期性孔道结构、大比表面积以及易于功能化修饰等优点,在气体储存/分离、催化、传感、生物成像和药物递送等领域得到了广泛应用。近些年,MOFs在疾病诊断和治疗方面,展现出了较大优势。本文综述了MOFs在生物传感、细胞成像、体内成像、药物递送等领域中的应用,探讨了MOFs在生物医药应用中仍存在的一些问题,并展望了解决方法,为设计新型疾病诊断和治疗方法提供参考。

Metal-organic frameworks(MOFs)are porous crystalline polymers constructed from the coordination reaction between organic ligands and metal ions.Due to their advantages:adjustable periodic pore structure,large specific surface area and easy functional modification,etc.,MOFs have been widely used in the fields of gas storage/separation,catalysis,sensing,biological imaging and drug delivery.In recent years,MOFs have shown great potential in disease diagnosis and treatment.This review summarizes the application of MOFs in the fields of bio-sensing,cell imaging,in vivo imaging,drug delivery,etc.,discusses the problems and corresponding solutions in the application of MOFs for biomedicine.We hope this review can provide reference for the designing new methods for disease diagnosis and treatment.