阿片类药物治疗鼻咽癌患者放射性口腔黏膜炎疼痛的研究进展

Research progress on opioids treatment of pain due to radiation-induced oral mucositis in nasopharyngeal carcinoma patients

放射性口腔黏膜炎(ROM)是鼻咽癌放射治疗中常见的并发症,所引起相关表现包括口腔黏膜疼痛、吞咽困难、进食减少以及继发性感染。其中,ROM引起的疼痛对患者生活质量和治疗进程的影响尤甚。因此,合理有效的疼痛管理在临床工作上尤为重要。近年来,随着改善癌症患者生存获益的临床试验开展,关于阿片类药物治疗鼻咽癌患者ROM疼痛的文献时有报道。该文拟对近年国内外关于鼻咽癌患者ROM疼痛的阿片类药物镇痛治疗的研究进展作一综述。

Radiation-induced oral mucositis(ROM) is a major complication of radiotherapy for nasopharyngeal carcinoma patients.The manifestations associated with ROM include oral mucosal pain,anorexia,odynophagia and secondary infections.Specifically,oral mucosal pain exerts extremely adverse impact on the quality of life and treatment process of patients.Therefore,rational and effective management of pain are of great significance.In recent years,clinical trials have been conducted to improve the survival benefit of cancer patients.In addition,application of opioids in treating ROM-induced pain in patients with nasopharyngeal carcinoma has been reported.In this article,research progress on the use of opioids in the treatment of ROM-induced pain in nasopharyngeal carcinoma patients was summarized.