外周血炎症标志物联合T淋巴细胞亚群检测在新型冠状病毒肺炎的临床价值探讨

Clinical value of blood inflammatory markers combined with T lymphocyte subsets in the detection of novel coronavirus pneumonia

目的 探讨白细胞(WBC)、C反应蛋白(CRP)和降钙素原(PCT)联合T淋巴细胞亚群检测在诊断新型冠状病毒肺炎(COVID-19)及细菌性肺炎中的临床价值。方法 回顾性分析COVID-19患者35例(COVID-19组)和细菌性肺炎患者40例(细菌性肺炎组)的临床资料,比较两组血常规、CRP、PCT、T淋巴细胞亚群值,并分析两组患者的临床资料及特征。结果 COVID-19组患者血WBC、淋巴细胞绝对值、CRP、PCT水平均低于细菌性肺炎组(P<0.05);COVID-19组CD3、CD4、CD8细胞绝对计数均低于细菌性肺炎组(P<0.05);而两组CD4/CD8比较,差异无统计学意义(P>0.05)。结论 联合检测外周血常规、CRP、PCT及T淋巴细胞亚群有助于COVID-19、细菌性肺炎的鉴别诊断,尤其在COVID-19疫情期间,对临床症状不典型的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染及疑似患者具有重要临床意义。

Objective To summarize the clinical characteristics of COVID-19 (Corona virus disease 2019) and bacterial pneumonia,and to explore the clinical value of white blood cell (WBC),C-reactive protein (CRP) and procalcitonin (PCT) combined with detection of T lymphocyte subgroup in the detection of novel COVID-19 and bacterial pneumonia.Methods The clinical data of 35 patients with COVID-19 and 40 patients with bacterial pneumonia were retrospectively analyzing,and all patients were tested for blood routine,CRP and PCT,T-lymphocyte subsets.The clinical data and characteristics of the two groups were analyzed.Results The levels of WBC,absolute value of lymphocytes,CRP and PCT in the COVID-19 group were significantly lower than those in the bacterial pneumonia group,and the difference between the two groups was statistically significant (P<0.05);absolute counts of CD3^+,CD4^+ and CD8^+ in COVID-19 group were significantly lower than those in the bacterial pneumonia group (P<0.05).However,there was no significant difference in CD4^+/CD8^+ between the two groups (P>0.05).Conclusions The combined detection of peripheral blood routine,CRP,PCT and T lymphocyte subsets is helpful for the differentiation of COVID-19 and bacterial pneumonia,especially during the outbreak of novel coronavirus pneumonia,which has important clinical significance for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection with atypical clinical symptoms and suspected patients.