丹参川芎嗪注射液治疗脑血栓的临床效果

Clinical effect of Salvia Miltiorrhizae and Ligustrazine Injection treating cerebral thrombosis

目的探讨丹参川芎嗪注射液治疗脑血栓的临床效果。方法选取2017年6月~2019年6月我院收治的114例脑血栓患者为研究对象,根据随机数字表分为对照组与观察组,每组各57例。对照组患者采用常规西药治疗,观察组患者采用丹参川芎嗪注射液治疗。比较两组患者治疗前后的中医证候积分、治疗总有效率以及治疗前后的超氧化物歧化酶(SOD)、丙二醛(MDA)、溶血磷脂酸(LPA)、内皮素(ET)。结果观察组患者的治疗总有效率(98.25%)高于对照组(84.21%),差异有统计学意义(P<0.05)。治疗后,观察组患者的中医证候积分[(8.53±1.24)分]低于对照组[(12.76±1.61)分],差异有统计学意义(P<0.05);治疗后,观察组患者的SOD含量[(107.64±14.54)U/ml]高于对照组[(88.96±12.36)U/ml],MDA[(5.56±0.72)μmol/L]、LPA[(1.70±0.25)μmol/L]、ET含量[(84.62±6.84)ng/L]低于对照组[(7.89±0.94)μmol/L、(2.53±0.33)μmol/L、(120.64±10.51)ng/L],差异有统计学意义(P<0.05)。结论对脑血栓患者在进行常规西药治疗的基础上,给予丹参川芎嗪注射液治疗,能有效调节患者的氧化应激反应,其应用效果显著,值得推广。

Objective To explore the clinical effect of Salvia Miltiorrhizae and Ligustrazine Injection treating cerebral thrombosis.Methods A total of 114 patients with cerebral thrombosis admitted to our hospital from June 2017 to June 2019 were selected as the research subjects.They were divided into control group and observation group according to the random number table method,57 cases in each group.The control group was treated with conventional western medicine.The observation group was treated with Salvia Miltiorrhizae and Ligustrazine Injection.The traditional Chinese medicine(TCM)syndrome scores before and after treatment,total effective rate of treatment,and superoxide dismutase(SOD),malondialdehyde(MDA),lysophosphatidic acid(LPA),and endothelin(ET)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group(98.25%)was higher than that in the control group(84.21%),and the difference was statistically significant(P<0.05).TCM syndrome score in the observation group([8.53±1.24]points)after treatment was lower than that in the control group([12.76±1.61]points),the difference was statistically significant(P<0.05).After treatment,the SOD content of patients in the observation group([107.64±14.54]U/ml)was higher than that in the control group([88.96±12.36]U/ml),MDA([5.56±0.72]μmol/L),LPA([1.70±0.25]μmol/L),ET([84.62±6.84]ng/L)content were lower than those in the control group([7.89±0.94]μmol/L,[2.53±0.33]μmol/L,[120.64±10.51]ng/L),the differences were statistically significant(P<0.05).Conclusion On the basis of conventional Western medicine treatment for patients with cerebral thrombosis,the treatment with Salvia Miltiorrhizae and Ligustrazine Injection can effectively regulate the patients′oxidative stress response,and its application effect is significant and worthy of promotion.