华蟾素片在结直肠癌术后患者化疗中的应用效果

Application effect of Huachansu Tablets in chemotherapy for postoperative patients with colorectal cancer

目的探讨华蟾素片在结直肠癌术后患者化疗中的应用效果。方法选取2018年1月~2019年1月我院收治的122例结直肠癌术后患者为研究对象,根据抽签分组法分为研究组(华蟾素片联合XELOX方案治疗)和对照组(XELOX方案治疗),每组各61例。对两组患者治疗前后的生活质量(KPS)评分、治疗前后的癌胚抗原(CEA)水平、不良反应发生情况进行比较。结果治疗前两组患者的KPS评分比较,差异无统计学意义(t=0.097,P>0.05),治疗后研究组患者KPS评分为(82.64±6.47)分,高于对照组的(76.41±5.47)分,差异有统计学意义(t=5.743,P<0.05);治疗前两组患者的CEA水平比较,差异无统计学意义(t=0.043,P>0.05),治疗后研究组患者的CEA水平为(2.78±0.66)μg/ml,低于对照组的(3.97±1.33)μg/ml,差异有统计学意义(t=6.260,P<0.05);研究组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论对结直肠癌术后化疗患者施以华蟾素片联合XELOX方案治疗,可以提升患者的生活质量和化疗效果,减少不良反应,临床应用价值高。

Objective To explore the application effect of Huachansu Tablets in chemotherapy for postoperative patients with colorectal cancer.Methods A total of 122 cases of postoperative patients with colorectal cancer treated in our hospital from January 2018 to January 2019 were selected as the research objects.They were divided into study group(Huachansu Tablets combined with XELOX regimen treatment)and control group(XELOX regimen treatment),61 cases in each group.The quality of life(KPS)scores,carcinoembryonic antigen(CEA)levels before and after treatment,and the incidence of adverse reactions of patients were compared between the two groups.Results There was no significant difference in KPS score between the two groups before treatment(t=0.097,P>0.05).After treatment,the KPS score of the study group was(82.64±6.47)points,which was higher than that of the control group of(76.41±5.47)points,the difference was statistically significant(t=5.743,P<0.05).The CEA levels of the two groups before treatment had no statistically significant difference(t=0.043,P>0.05),and the CEA of the study group after treatment was(2.78±0.66)μg/ml,which was lower than that of the control group of(3.97±1.33)μg/ml,the difference was statistically significant(t=6.260,P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of colorectal cancer patients undergoing chemotherapy with Huachansu Tablets combined with XELOX regimen can improve the quality of life and chemotherapy effect of patients,reduce adverse reactions,and have high clinical application value.