纳米诊疗研究进展

Research advances in nanotheranostics

为了实现肿瘤的个体化精准医疗,"纳米诊疗"领域应运而生.本文介绍了纳米诊疗领域发展过程中重要进展的时间线,详细分析了该领域研究论文发表情况,包括论文发表数量、主要研究机构、主要支持基金以及重要杂志等,并进一步详细综述了纳米诊疗平台的构建策略和重要研究进展.纳米诊疗平台的构建策略是将靶向递送、诊断和治疗功能结合在同一个纳米载体上,这种纳米载体可以是聚合物纳米颗粒、脂质体纳米颗粒或是无机纳米颗粒,以实现多种成像模式联合诊断,多种治疗方法协同治疗,以及诊疗一体化等独特功能.纳米诊疗剂通向临床之路困难重重,但精准医疗是未来医学发展的大趋势,诊疗纳米颗粒的临床使用和研究必然具有巨大的发展潜力.

Nanotheranostics is the field of achieving personalized precision medicine in tumor diagnosis and treatment.This review introduces the timeline of important advances in nanotheranostics and analyzes the literature in this field,including the number of published papers,research institutions,supporting funds,and important journals.The nanotheranostics platform construction strategy and important research advances are reviewed in detail.The nanotheranostics platform construction strategy is to integrate target delivery,imaging,and treatment in one nanocarrier,which can be either a polymer,liposome,or inorganic nanoparticle,to achieve multimodality imaging,synergy treatments,and theranostics.Although nanotheranostic agents are difficult to obtain at the clinic,precision medicine is the general trend of future medical development,and the research and clinical application of nanotheranostic particles are bound to have great development potential.