法舒地尔联合马来酸桂哌齐特治疗动脉瘤性蛛网膜下腔出血术后脑血管痉挛的效果观察

Efficacy of fasudil combined with cinepazide maleate in treatment of cerebral vasospasm after aneurysm subarachnoid hemorrhage

目的探究法舒地尔联合马来酸桂哌齐特治疗动脉瘤性蛛网膜下腔出血术后脑血管痉挛的疗效。方法选取2016年3月-2018年12月在某医院接受治疗的动脉瘤性蛛网膜下腔出血术后脑血管痉挛患者84例,按照随机对照原则分成对照组和观察组,均先接受常规治疗。对照组42例,给予盐酸法舒地尔注射液治疗;观察组42例,采用盐酸法舒地尔注射液联合马来酸桂哌齐特注射液治疗,治疗周期均为14 d。对比两组患者治疗前后的格拉斯哥昏迷评分(GCS)、白细胞介素6(IL-6)水平及脑动脉血流动力学指标。结果治疗14 d后,观察组患者的GCS评分为(4.42±0.87)分,高于对照组的(3.18±0.82)分,IL-6水平为(9.64±2.16)pg/mL、脑中动脉收缩缝流速为(81.35±10.16)cm/s均低于对照组:(13.54±2.37)pg/mL、(93.78±11.65)cm/s,差异有统计学意义(P<0.05)。结论法舒地尔联合马来酸桂哌齐特治疗动脉瘤性蛛网膜下腔出血术后脑血管痉挛,能够有效抑制患者炎症反应,扩张血管,降低脑中动脉收缩缝流速,缓解脑血管痉挛。

Objective To investigate the efficacy of fasudil combined with cinepazide maleate in the treatment of cerebral vasospasm after aneurysm subarachnoid hemorrhage.MethodsFrom March 2016 to December 2018, 84 patients with cerebral vasospasm after aneurysm subarachnoid hemorrhage were randomly divided into a control group and a trial group. The control group(n = 42) was treated with fasudil hydrochloric acid injection, and the trial group(n = 42) was treated with fasudil hydrochloric acid injection combined with cinepazide maleate injection for 14 days. The Glasgow coma scores(GCS), IL-6(IL-6) levels and cerebral artery hemodynamics were measured and compared between two groups before and after the treatment.ResultsFourteen days after the treatment, the GCS score of the patients of the trial group was(4.42±0.87) points, which was higher than that of the control group [(3.18±0.82) points]. The level of IL-6 was(9.64±2.16)pg/mL and the mean blood flow velocity of the cerebral artery was(81.35±10.16) cm/s of the trial group, which were significantly lower than those of the control group [(13.54 ±2.37) pg/mL and(93.78±11.65) cm/s respectively, (P<0.05)].ConclusionThe fasudil combined with cinepazide maleate in the treatment of cerebral vasospasm after aneurysm subarachnoid hemorrhage can effectively inhibit the inflammatory reaction, dilate blood vessels, reduce the average blood flow velocity of cerebral artery, and relieve cerebral vasospasm, and the efficacy is obvious.