重症肌无力肌群耐力评分量表信度效度评价

Evaluation of reliability and validity of muscular endurance scale of myasthenia gravis

目的评价重症肌无力肌群耐力评分量表(Myasthenia Gravis muscular endurance scale,MGMES)在中国重症肌无力(myasthenia gravis,MG)患者中的信度与效度。方法选取MG患者60例,固定由2~3名MG专科医师,应用重症肌无力定量评分(Quantitative Myasthenia Gravis Score,QMGS)、重症肌无力复合量表(Myasthenia GravisComposite,MGC)、重症肌无力绝对和相对评分法(Absolute and Relative Score of MG,ARS-MG)和MGMES进行检查评分。量表内部一致性通过Cronbach′sα系数进行评价,量表重测信度通过组内相关系数(intraclass correlation efficient,ICC)进行评价,量表结构效度通过KMO(Kaiser-Meyer-Olkin)检验、Bartlett球型检验和因子分析法进行评价;校标关联效度和量表之间的相关性通过Spearman相关系数进行评价。结果MGMES具有良好的内部一致性(Cronbach′sα为0.854)和重测信度(ICC为0.987,P<0.01)。有4项公因子,累积方差贡献率69.51%,结构效度良好。与QMGS高度相关(r=0.806,P<0.01),与MGC、ARS-MG中度相关(r=0.745、0.675,P<0.01)。结论MGMES具有良好的信度和效度,能够较全面、准确体现MG的严重程度,可以进一步在临床应用中推广。

Objective To evaluate the validity and reliability of myasthenia gravis muscular endurance scale(MGMES)among myasthenia gravis(MG)patients in China.Methods Altogether 60 patients with myasthenia gravis were selected to receive examination and evaluation by 2-3 MG specialist physicians in accordance with Quantitative Myasthenia Gravis Score(QMGS),Myasthenia Gravis Composite(MGC),Absolute and Relative Score of MG(ARS-MG)and MGMES.As for MGMES,the internal consistency was assessed by Cronbach'sαcoefficient,the test-retest reliability was evaluated byintraclass correlation efficient(ICC),and the structural validity the test-retest reliability was evaluated by KMO(Kaiser-Meyer-Olkin)test,Bartlett's test of sphericity,and factor analysis.The correlation between criterion-related validity and scales was evaluated using Spearman correlation coefficient.Results The scale had good internal consistency(Cronbach′sα=0.854)and test-retest reliability(ICC=0.987,P<0.01).There were 4 common factors,the cumulative variance contribution rate was 69.51%,and the construct validity was good.It was highly correlated with QMGS(r=0.806,P<0.01),moderately correlated with MGC and ARS-MG(r=0.745,r=0.675,P<0.01).Conclusion The MGMES is proven to have good validity and reliability,as it can reflect the severity of MG in a relatively comprehensive and accurate way.Thus,it can be further promoted in the clinical practice.