肠道微生物对肿瘤发生发展及化疗药物的影响

Effect of gut microbiota on tumor development and chemotherapy drugs

肠道微生物群在多种肿瘤发生发展过程中的作用引起了人们的广泛关注,近几年大量研究表明微生物群与肿瘤之间有着密切的关系。它们不仅可以与宿主共代谢,对肿瘤治疗产生正面或负面影响,还可以直接促进或消除化疗药物的疗效并介导药物的毒性,从而干预肿瘤的治疗。此外,肠道微生物能够介导免疫疗法,增强患者对肿瘤的免疫应答能力。在此综述中,我们概述了肠道微生物在肿瘤治疗中的意义,揭示其对化疗药物及免疫疗法的影响,并总结多种治疗肿瘤的潜在机制。不仅展现了肠道微生物研究对临床治疗肿瘤的意义,也为临床协助肿瘤治疗提供更多的思路。

The role of gut microbiota in the development of various tumors has been raising public awareness.In recent years,a large number of studies have shown there is a close relationship between microbial groups and the manifestation of tumors.Gut microbiota not only metabolize with the host,but also positively or negatively affect the treatment of tumor by improving or eliminating the effects of chemotherapy drugs and mediating the toxicity of drugs.Besides,they can enhance the ability of patients′immune response to tumors in mediating immunotherapy.In this review,we outlined the significance of gut microbiota in the treatment of tumors,and explored their impacts on chemotherapy drugs and immunotherapy.We also analyzed various potential mechanisms for treating tumors and revealed the significance of intestinal microbial research to clinical treatment of tumors,in order to provide more ideas for clinical treatment of cancers.