益生菌在腹型过敏性紫癜中临床应用的研究进展

Progress in research on probiotics in the treatment of abdominal type of Henoch-Schonlein purpura

过敏性紫癜(HSP)是儿童最常见的自身免疫性疾病之一,临床表现除皮疹外以消化道症状最为常见,严重影响患儿的生活质量。临床上治疗腹型HSP主要以糖皮质激素和抗组胺药物为主,但只能缓解病情,不能达到根治的目的,同时还存在一定的副作用。最近有学者对腹型HSP患者中肠道微生物区系中的细菌数量进行精确测量,发现腹型HSP可能与肠道菌群失调有关。益生菌是一类在适当摄入数量会对宿主机体带来益处的活的微生物,是调节机体微生态平衡的有效途径,可通过多种途径来增强肠道屏障功能、提高机体自身免疫力和降低变态反应性,从而使其在腹型HSP中具有治疗潜力。本文对益生菌在腹型HSP中的临床应用作一综述。

Henoch-Schonlein purpura(HSP)is one of the most common autoimmune diseases in children.Except for rash,digestive tract symptoms are the most common symptoms.It seriously affects the quality of life of children.Glucocorticoid and antihistamines are the main drugs used to treat HSP in clinical practice,which can only alleviate the symptoms but cannot achieve eradication of the disease.And they also have some side effects.Recent studies have found that the precise measurement of the number of bacteria in the intestinal microflora of abdominal HSP patients suggests that abdominal type of HSP may be associated with intestinal flora disorders.Probiotics are a kind of living microorganisms which can bring benefit to host body when intaking in proper quantity.It is an effective way to regulate the microecological balance of organism with probiotics.They can enhance the function of intestinal barrier and the immunity of the host through many ways,and reduce allergic reactions,which makes them potential therapeutic drugs for abdominal HSP.This article reviews the clinical application of probiotics in treatment of abdominal HSP.