卵巢癌术后化疗联合顺铂腹腔热灌注的应用效果及对患者生存率的影响

Application effect of postoperative chemotherapy combined with cisplatin intraperitoneal hyperfusion for ovarian cancer and its influence on survival rate of patients

目的探讨卵巢癌术后化疗联合顺铂腹腔热灌注的应用效果及对患者生存率的影响。方法选取70例卵巢癌手术患者作为研究对象,以数字表法将其随机分为对照组和观察组,每组35例。对照组术后予以化疗,观察组则采用化疗联合顺铂腹腔热灌注治疗。比较两组的治疗效果。结果观察组客观缓解率高于对照组(P<0.05);治疗后,观察组的QOL评分高于对照组(P<0.05);观察组的1年及2年生存率高于对照组(P<0.05)。结论化疗联合顺铂腹腔热灌注应用于卵巢癌术后治疗中,有助于提高治疗效果、延长患者生存时间,且不会明显增加不良反应,值得临床推广。

Objective To investigate the application effect of postoperative chemotherapy combined with cisplatin intraperitoneal hyperfusion for ovarian cancer and its influence on survival rate of patients.Methods Seventy patients undergoing ovarian cancer surgery were selected as the research objects and randomly divided into control group and observation group by the number table method,with 35 cases in each group.The control group was given chemotherapy after operation,while the observation group was treated with chemotherapy combined with cisplatin intraperitoneal hyperfusion.The treatment effect was compared between the two groups.Results The objective remission rate in the observation group was higher than that in the control group(P<0.05).After treatment,QOL score of the observation group was higher than that of the control group(P<0.05).The 1-year and 2-year survival rates in the observation group were higher than those in the control group(P<0.05).Conclusion Chemotherapy combined with cisplatin intraperitoneal hyperfusion in the postoperative treatment of ovarian cancer is helpful to improve the therapeutic effect and prolong the patient's survival time,without significantly increasing adverse reactions,which is worthy of clinical promotion.