乌司他丁联合奥斯他韦治疗重症甲型H1N1流感肺炎患者的效果

Effect of ulinastatin combined with oseltamivir in the treatment of patients with severe influenza A H1N1 pneumonia

目的探究乌司他丁联合奥司他韦治疗重症甲型H1N1流感肺炎患者的效果。方法选择在本院进行治疗的重症甲型H1N1流感肺炎患者100例,采用抽签方式将其分为观察组和对照组,各50例。观察组给予乌司他丁联合奥司他韦治疗,对照组给予奥司他韦治疗。比较两组治疗效果。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组IL-6、IL-8、TNF-α水平均降低,IL-10水平升高,且观察组优于对照组(P<0.05)。治疗后,两组CD3+、CD4+水平和CD4+/CD8+升高,CD8+水平降低,且观察组优于对照组(P<0.05)。治疗后,两组CK和CTnT水平均降低,且观察组低于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论乌司他丁联合奥司他韦治疗重症甲型H1N1流感肺炎效果显著,能减轻患者炎症因子水平,调节T淋巴细胞亚群水平,且安全可靠。

Objective To explore the effect of ulinastatin combined with oseltamivir in the treatment of patients with severe influenza A H1N1 pneumonia.Methods A total of 100 patients with severe influenza A H1N1 pneumonia treated in our hospital were selected,and they were divided into observation group and control group adopting the drawing lots method,with 50 cases in each group.The observation group was treated with ulinastatin combination with oseltamivir,the control group was treated with oseltamivir.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).After treatment,the IL-6,IL-8 and TNF-αlevels in the two groups decreased,the IL-10 level increased,and those of the observation group were better than the control group(P<0.05).After treatment,the CD3+,CD4+levels and CD4+/CD8+in the two groups increased,and the CD8+level decreased,and those of the observation group were better than the control group(P<0.05).After treatment,CK and CTnT levels in the two groups decreased,and those of the observation group were lower than the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Ulinastatin combination with oseltamivir has a significant effect on patients with severe influenza A H1N1 pneumonia,which can reduce the levels of inflammatory factors,regulate the level of T lymphocyte subsets,and is safe and reliable.